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Specific immunoglobulin E and immunoglobulin G antibodies to toluene diisocyanate-human serum albumin conjugate: useful markers for predicting long-term prognosis in toluene diisocyanate-induced asthma.

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dc.contributor.authorPark, HS-
dc.contributor.authorLee, SK-
dc.contributor.authorKim, HY-
dc.contributor.authorNahm, DH-
dc.contributor.authorKim, SS-
dc.description.abstractBACKGROUND: Our previous study reported that more than 50% of toluene diisocyanate (TDI)-induced asthma patients had persistent asthmatic symptoms even after complete avoidance. Although specific IgE (sIgE) has been detected in a portion of patients with TDI-asthma, a recent investigation suggests that the presence of serum specific IgG (sIgG), not sIgE, is more closely associated with positive bronchoprovocation test (BPT) results.

OBJECTIVE: To evaluate the possible role of sIgE and sIgG in predicting long-term prognosis of TDI-asthma.

MATERIALS AND METHODS: Forty-one TDI-asthma patients whose diagnosis was confirmed by TDI-BPT, and 20 unexposed healthy controls were enrolled. Both sIgE and sIgG to TDI-human serum albumin (HSA) conjugate were detected by ELISA. All patients with persistent asthmatic symptoms took anti-asthmatic medications during the follow-up period (mean: 67.5 months) and were instructed to avoid exposure to TDI. Airway hyper-responsiveness to methacholine (AHM) was monitored every year during the study period. The patients were classified into three groups according to changing patterns of AHM and asthmatic symptoms as follows: group I, no improvement with persistent asthmatic symptoms (n = 12); group II, partial improvement with persistent asthmatic symptoms (n = 13); group III, in remission (n = 16).

RESULTS: Favourable prognosis was associated with a mild degree of AHM at initial diagnosis (P < 0.05). Although there were no significant differences in the prevalence of sIgE antibody to TDI-HSA conjugate among the three groups (P > 0.05), prevalence of sIgG in group I tended to be higher than in group II (0.05 < P < 0.1). However, the levels of sIgG were significantly higher in group I than in group II (P = 0.05), whereas levels of sIgE were significantly higher in group II than in group I (P = 0.014). No significant differences were noted in exposure duration, sex, age, atopic status, and total IgE level among the three groups (P > 0.05).

CONCLUSION: This study confirmed that a favourable outcome is related to a mild degree of AHM and to low levels of sIgG to predict persistent asthmatic symptoms, it also suggested that the presence of high serum-specific IgE at initial diagnosis may represent a better prognosis.
dc.subject.MESHBiological Markers-
dc.subject.MESHBronchial Hyperreactivity-
dc.subject.MESHImmunoglobulin E-
dc.subject.MESHImmunoglobulin G-
dc.subject.MESHSerum Albumin-
dc.subject.MESHToluene 2,4-Diisocyanate-
dc.titleSpecific immunoglobulin E and immunoglobulin G antibodies to toluene diisocyanate-human serum albumin conjugate: useful markers for predicting long-term prognosis in toluene diisocyanate-induced asthma.-
dc.contributor.affiliatedAuthor박, 해심-
dc.contributor.affiliatedAuthor남, 동호-
dc.type.localJournal Papers-
dc.citation.titleClinical and experimental allergy-
dc.identifier.bibliographicCitationClinical and experimental allergy, 32(4). : 551-555, 2002-
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Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
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