Cited 0 times in Scipus Cited Count

Effect of cyclosporin A on melanogenesis in cultured human melanocytes.

DC Field Value Language
dc.contributor.authorLee, JY-
dc.contributor.authorKang, WH-
dc.date.accessioned2011-07-21T03:15:18Z-
dc.date.available2011-07-21T03:15:18Z-
dc.date.issued2003-
dc.identifier.issn0893-5785-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/3491-
dc.description.abstractCyclosporin A (CsA) is a widely used immunosuppressant. Reports on the effect of CsA on hyperpigmentation in patients appear inconsistent, and the effect of CsA on skin pigment cells (melanocytes) in vitro is unknown. We examined the effect of CsA on human melanocyte proliferation and melanogenesis in vitro. Melanocyte proliferation was dose-dependently inhibited by 0.1-10 microM CsA, with no effect on cell viability. Melanocytes incubated with 10 microM CsA for 6 days showed decreased pigmentation and tyrosinase activity. Western blot analysis using an anti-tyrosinase antibody revealed that CsA (0.1-10 microM) decreased tyrosinase protein levels in a dose-dependent manner. Northern blot analysis showed similar effects on tyrosinase mRNA levels. These effects of CsA on melanogenesis in vitro are not consistent with suggestions that systemic CsA therapy causes patient skin hyperpigmentation.-
dc.language.isoen-
dc.subject.MESHCell Division-
dc.subject.MESHCells, Cultured-
dc.subject.MESHCyclosporine-
dc.subject.MESHDose-Response Relationship, Drug-
dc.subject.MESHHumans-
dc.subject.MESHImmunosuppressive Agents-
dc.subject.MESHMelanins-
dc.subject.MESHMelanocytes-
dc.subject.MESHMonophenol Monooxygenase-
dc.subject.MESHPigmentation-
dc.titleEffect of cyclosporin A on melanogenesis in cultured human melanocytes.-
dc.typeArticle-
dc.identifier.pmid12950728-
dc.identifier.urlhttp://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0893-5785&date=2003&volume=16&issue=5&spage=504-
dc.contributor.affiliatedAuthor강, 원형-
dc.type.localJournal Papers-
dc.citation.titlePigment cell research-
dc.citation.volume16-
dc.citation.number5-
dc.citation.date2003-
dc.citation.startPage504-
dc.citation.endPage508-
dc.identifier.bibliographicCitationPigment cell research, 16(5). : 504-508, 2003-
dc.identifier.eissn1600-0749-
dc.relation.journalidJ008935785-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Dermatology
Files in This Item:
There are no files associated with this item.

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse