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Immortalization of normal adult human middle ear epithelial cells using a retrovirus containing the E6/E7 genes of human papillomavirus type 16.

DC Field Value Language
dc.contributor.authorChun, YM-
dc.contributor.authorMoon, SK-
dc.contributor.authorLee, HY-
dc.contributor.authorWebster, P-
dc.contributor.authorBrackmann, DE-
dc.contributor.authorRhim, JS-
dc.contributor.authorLim, DJ-
dc.date.accessioned2011-07-22T01:46:40Z-
dc.date.available2011-07-22T01:46:40Z-
dc.date.issued2002-
dc.identifier.issn0003-4894-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/3519-
dc.description.abstractA human middle ear epithelial cell line (HMEEC-1) was established using human papillomavirus E6/E7 genes. HMEEC-1 has remained morphologically and phenotypically stable, even after 50 passages. The cells are anchorage-dependent and nontumorigenic when injected into nude mice. This cell line thus provides a new tool for the study of normal cell biology and the pathological processes associated with the epithelial cells of the middle ear in otitis media. HMEEC-1 will also be useful in the search for new drugs and biological agents for the treatment of otitis media.-
dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAnimals-
dc.subject.MESHCell Line-
dc.subject.MESHEar, Middle-
dc.subject.MESHEpithelial Cells-
dc.subject.MESHGenetic Vectors-
dc.subject.MESHHumans-
dc.subject.MESHMice-
dc.subject.MESHMice, Nude-
dc.subject.MESHOncogene Proteins, Viral-
dc.subject.MESHPapillomaviridae-
dc.subject.MESHPapillomavirus E7 Proteins-
dc.subject.MESHRepressor Proteins-
dc.subject.MESHReverse Transcriptase Polymerase Chain Reaction-
dc.titleImmortalization of normal adult human middle ear epithelial cells using a retrovirus containing the E6/E7 genes of human papillomavirus type 16.-
dc.typeArticle-
dc.identifier.pmid12090706-
dc.contributor.affiliatedAuthor문, 성균-
dc.type.localJournal Papers-
dc.identifier.doi10.1177/000348940211100606-
dc.citation.titleThe Annals of otology, rhinology, and laryngology-
dc.citation.volume111-
dc.citation.number6-
dc.citation.date2002-
dc.citation.startPage507-
dc.citation.endPage517-
dc.identifier.bibliographicCitationThe Annals of otology, rhinology, and laryngology, 111(6). : 507-517, 2002-
dc.identifier.eissn1943-572X-
dc.relation.journalidJ000034894-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Otolaryngology
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