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The origin of cells that repopulate patellar tendons used for reconstructing anterior cruciate ligaments in man.

Authors
Min, BH; Han, MS; Woo, JI; Park, HJ; Park, SR
Citation
The Journal of bone and joint surgery. British volume, 85(5):753-757, 2003
Journal Title
The Journal of bone and joint surgery. British volume
ISSN
0301-620X
Abstract
Cryopreserved patellar tendon allografts are often recommended for reconstruction of anterior cruciate ligaments (ACLs) because living donor fibroblasts are thought to promote repair. Animal studies, however, indicate that ligaments regenerate from recipient rather than donor cells. If applicable to man, these observations suggest that allograft cell viability is unimportant. We therefore used short tandem repeat analysis with polymerase chain reaction (PCR) amplification to determine the source of cells in nine human ACLs reconstructed with cryopreserved patellar tendon allografts. PCR amplification of donor and recipient DNA obtained before operation and DNA from the graft obtained two to ten months after transplantation revealed the genotype of cells and showed only recipient cells in the graft area. Rather than preserve the viability of donor cells, a technique is required which will facilitate the introduction of recipient cells into patellar tendon allografts.
MeSH terms
AdultAnterior Cruciate Ligament/cytology*Cryopreservation/methodsDNA/analysisFemaleGenotypeHumansMalePatella*Polymerase Chain Reaction/methodsTandem Repeat Sequences/geneticsTendons/cytology*Tendons/transplantationTransplantation, Homologous
PMID
12892205
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Orthopedic Surgery
AJOU Authors
민, 병현
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