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Drugs targeting Toll-like receptors.

Authors
Krishnan, J; Lee, G; Choi, S
Citation
Archives of pharmacal research, 32(11):1485-1502, 2009
Journal Title
Archives of pharmacal research
ISSN
0253-6269
Abstract
Animals and plants are exposed to myriads of potential microbial invaders. In case of animals, Toll-like receptors (TLRs) act as the primary defense against infection by pathogens. Arguably, less is known regarding the activation of TLRs that connect the innate and adaptive immune systems. Some TLR ligands have been used as adjuvants in various vaccines and have gained a great deal of attention due to their ability to elicit an effective immune response. Understanding the intricate relationships between various molecules involved in TLR signaling and their positive or negative regulation is a key focus for the development of effective therapeutics. In this review, recent developments in TLR signaling that will be very important in providing new drug target molecules and a better understanding of molecular regulation of innate immunity are discussed.
MeSH terms
Adjuvants, Immunologic/pharmacologyAnimalsDrug Delivery Systems*HumansImmunity, InnateLigandsSignal Transduction/drug effects*Toll-Like Receptors/drug effectsToll-Like Receptors/immunology*
DOI
10.1007/s12272-009-2100-6
PMID
20091261
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
AJOU Authors
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