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Neuroprotective effects of constituents of the oriental crude drugs, Rhodiola sacra, R. sachalinensis and Tokaku-joki-to, against beta-amyloid toxicity, oxidative stress and apoptosis.

Authors
Mook-Jung, I; Kim, H; Fan, W; Tezuka, Y; Kadota, S; Nishijo, H; Jung, MW
Citation
Biological & pharmaceutical bulletin, 25(8):1101-1104, 2002
Journal Title
Biological & pharmaceutical bulletin
ISSN
0918-61581347-5215
Abstract
We tested the constituents of two Rhodiola plants, Rhodiola sacra S. H. Fu and R. sachalinensis A. BOR, and an Oriental crude drug, Tokaku-joki-to, for their neuroprotective effects. Of the 58 compounds tested, six had considerable protective effects against beta-amyloid-induced death of B103 neuronal cells in vitro. These six compounds also showed protective effects against staurosporine-induced cell death, and two of the six compounds protected neurons from H2O2-induced cell death. These results suggest that some of the tested compounds protect neurons from beta-amyloid toxicity based on antiapoptotic and antioxidative activity.
MeSH terms
Amyloid beta-Peptides/antagonists & inhibitors/*toxicityAnimalsApoptosis/*drug effects/physiologyCell Survival/drug effects/physiologyCells, CulturedDrugs, Chinese Herbal/chemistry/isolation & purification/*pharmacologyNeuroprotective Agents/chemistry/isolation & purification/*pharmacologyOxidative Stress/*drug effects/physiologyPlant Structures/chemistryRats*Rhodiola/chemistryStructure-Activity Relationship
PMID
12186418
Appears in Collections:
Journal Papers > Research Organization > Brain Disease Research Center
Journal Papers > Research Organization > Institute for Medical Sciences
AJOU Authors
묵, 인희정, 민환
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