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ATP-induced in vivo neurotoxicity in the rat striatum via P2 receptors.

Authors
Ryu, JK; Kim, J; Choi, SH; Oh, YJ; Lee, YB; Kim, SU; Jin, BK
Citation
Neuroreport, 13(13):1611-1615, 2002
Journal Title
Neuroreport
ISSN
0959-49651473-558X
Abstract
The present study examined the effects of ATP on the striatum of Sprague-Dawley rats. Intrastriatal administration of ATP produced dose-dependent striatal lesions as confirmed by cresyl violet staining. Additional immunostaining using neuronal nuclear protein (NeuN), OX-42 and GFAP antibodies revealed that ATP caused death of both neurons and glial cells. The nonmetabolizable ATP analogue ATPgammaS and P2X receptor agonist alpha,beta-methylene ATP (alpha,beta-MeATP) mimicked ATP effects, whereas either P2Y receptor agonist ADP or P1 receptor agonist adenosine did not. The P2 receptor antagonist reactive blue 2, but not pyridoxal-phosphate-6-azophenyl-2',4'-disulphonic acid (PPADS) attenuated ATP-induced striatal injury. These results suggest that intrastriatal administration of ATP causes P2X receptor-mediated cell death in the striatum and support the hypothesis that extracellular ATP can be an important mediator of neuropathological events of brain injuries.
MeSH terms
Adenosine Triphosphate/analogs & derivatives/*metabolism/pharmacologyAnimals*Antigens, CDAntigens, CD147*Antigens, Neoplasm*Antigens, SurfaceAstrocytes/drug effects/metabolism/pathology*Avian Proteins*Blood ProteinsCell Death/drug effects/physiologyDose-Response Relationship, DrugFemaleGlial Fibrillary Acidic Protein/metabolismHypoxia-Ischemia, Brain/*metabolism/physiopathologyMembrane Glycoproteins/metabolismMicroglia/drug effects/metabolism/pathologyNeostriatum/drug effects/*metabolism/physiopathologyNerve Degeneration/chemically induced/metabolism/physiopathologyNeuroglia/drug effects/*metabolism/pathologyNeurons/drug effects/*metabolism/pathologyNeurotoxins/*metabolism/toxicityPurinergic P1 Receptor AgonistsPurinergic P1 Receptor AntagonistsPurinergic P2 Receptor AgonistsPurinergic P2 Receptor AntagonistsRatsRats, Sprague-DawleyReceptors, Purinergic P1/metabolismReceptors, Purinergic P2/*metabolismReceptors, Purinergic P2X
PMID
12352612
Appears in Collections:
Journal Papers > Research Organization > Institute for Medical Sciences
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
AJOU Authors
이, 용범김, 승업진, 병관
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