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Bone scintigraphy of skeletal metastasis in hepatoma patients treated by TAE.

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dc.contributor.authorLee, KH-
dc.contributor.authorPark, JM-
dc.contributor.authorYoon, JK-
dc.contributor.authorKoh, KC-
dc.contributor.authorPaik, SW-
dc.contributor.authorKim, BT-
dc.date.accessioned2011-07-26T04:36:04Z-
dc.date.available2011-07-26T04:36:04Z-
dc.date.issued2003-
dc.identifier.issn0172-6390-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/3596-
dc.description.abstractBACKGROUND/AIMS: Skeletal metastasis in hepatocellular carcinoma patients has become clinically important as a result of advances in treatment modalities. However, the diagnostic accuracy of bone scintigraphy in hepatocellular carcinoma has been questioned.



METHODOLOGY: 99mTc-MDP bone scintigraphy was performed in 63 unresectable hepatocellular carcinoma patients treated by transcatheter arterial embolization who either developed musculoskeletal pain (n = 43) or elevated serum alpha-fetoprotein levels (n = 20) during follow-up. Results were categorized as positive or negative for metastases, and their accuracy was evaluated by radiological studies, biopsy, and clinical follow-up.



RESULTS: Bone scintigraphy was positive in 22/43 (51.2%) subjects with pain and 2/20 with alpha-feto-protein elevation. Among 24 bone scintigraphy(+) patients, metastasis was confirmed in 17 and excluded in 6. Frequent sites for metastatic bone scintigraphy lesions were the spine, pelvic bone and ribs. Although 8 metastatic lesions had low or mixed uptake, most had increased uptake on bone scintigraphy. Among 39 bone scintigraphy(-) patients, metastasis was excluded in 32 and confirmed in 1. The sensitivity and specificity of bone scintigraphy in this subset of patients was 94.4% and 84.2%, respectively.



CONCLUSIONS: Transcatheter arterial embolization treated hepatocellular carcinoma patients with musculoskeletal pain have a high likelihood of bone metastasis, and bone scintigraphy is a highly reliable method for its detection.
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dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBone Neoplasms-
dc.subject.MESHCarcinoma, Hepatocellular-
dc.subject.MESHEmbolization, Therapeutic-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHLiver-
dc.subject.MESHLiver Function Tests-
dc.subject.MESHLiver Neoplasms-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPain Measurement-
dc.subject.MESHRadionuclide Imaging-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSensitivity and Specificity-
dc.subject.MESHTechnetium Tc 99m Medronate-
dc.subject.MESHalpha-Fetoproteins-
dc.titleBone scintigraphy of skeletal metastasis in hepatoma patients treated by TAE.-
dc.typeArticle-
dc.identifier.pmid14696448-
dc.contributor.affiliatedAuthor윤, 준기-
dc.type.localJournal Papers-
dc.citation.titleHepato-gastroenterology-
dc.citation.volume50-
dc.citation.number54-
dc.citation.date2003-
dc.citation.startPage1983-
dc.citation.endPage1986-
dc.identifier.bibliographicCitationHepato-gastroenterology, 50(54). : 1983-1986, 2003-
dc.relation.journalidJ001726390-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Nuclear Medicine & Molecular Imaging
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