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Mechanism for antiplatelet effect of onion: AA release inhibition, thromboxane A(2)synthase inhibition and TXA(2)/PGH(2)receptor blockade.

Authors
Moon, CH; Jung, YS; Kim, MH; Lee, SH; Baik, EJ; Park, SW
Citation
Prostaglandins, leukotrienes, and essential fatty acids, 62(5):277-283, 2000
Journal Title
Prostaglandins, leukotrienes, and essential fatty acids
ISSN
0952-32781532-2823
Abstract
Antiplatelet actions of aqueous extract of onion were investigated in rat and human platelet. IC(50)values of onion extract for collagen-, thrombin-, arachidonic acid (AA)-induced aggregations and collagen-induced thromboxane A(2)(TXA(2)) formation were 0.17 +/- 0. 01, 0.23 + 0.03, 0.34 +/- 0.02 and 0.12 +/- 0.01 g/ml, respectively. [(3)H]-AA release induced by collagen (10 microg/ml) in rat platelet was decreased by onion compared to control (22.1 +/- 2.13 and 5.2 +/- 0.82% of total [(3)H]-AA incorporated, respectively). In fura-2 loaded platelets, the elevation of intracellular Ca(2+)concentration stimulated by collagen was inhibited by onion. Onion had no cytotoxic effect in platelet. Onion significantly inhibited TXA(2)synthase activity without influence on COX activity. Platelet aggregation induced by U46619, a stable TXA(2)mimetic, was inhibited by onion, indicating its antagonism for TXA(2)/PGH(2)receptor. These results suggest that the mechanism for antiplatelet effect of onion may, at least partly, involve AA release diminution, TXA(2)synthase inhibition and TXA(2)/PGH(2)receptor blockade.
MeSH terms
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid/pharmacologyAnimalsBlood Platelets/drug effects/metabolismDose-Response Relationship, DrugHumansInhibitory Concentration 50Onions/*therapeutic use*PhytotherapyPlant Extracts/pharmacologyPlatelet Aggregation/drug effectsPlatelet Aggregation Inhibitors/*pharmacologyProstaglandin-Endoperoxide Synthases/drug effects/metabolismRatsRats, Sprague-DawleyThromboxane A2/biosynthesisThromboxane B2/metabolismThromboxane-A Synthase/metabolismVasoconstrictor Agents/pharmacology
DOI
10.1054/plef.2000.0155
PMID
10883058
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
AJOU Authors
문, 창현정, 이숙이, 수환백, 은주
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