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Combined treatment with colchicine and Herba Taraxaci (Tarazacum mongolicum Hand.-Mazz.) attenuates Behcet's disease-like symptoms in mice and influences the expressions of cytokines.

Authors
Sohn, S; Bang, D; Lee, SI; Kim, YA; Lee, ES; Ha, JY; Kim, JH; Choi, SY; Lee, S
Citation
International immunopharmacology, 3(5):713-721, 2003
Journal Title
International immunopharmacology
ISSN
1567-57691878-1705
Abstract
Herbal medicine, Herba Taraxaci (Tarazacum mongolicum Hand.-Mazz.), was administered to mice with Behcet's disease (BD)-like symptoms induced by herpes simplex virus (HSV). BD is a chronic recurrent inflammatory disease. Herba Taraxaci (6 mg) was administered alone or in combination with 2 microg of colchicine to BD-like mice. Colchicine is a drug that is widely used as a medication for BD patients. The water extracts of Herba Taraxaci were administered orally once per day for 20 days. Eighty percent (8 of 10) of mice treated with Herba Taraxaci combined with colchicine showed improvement in mucocutaneous symptoms compared to 0% (0 of 10) of the nontreated group and 30% (3 of 10) treated with colchicine alone. Cytokine expression in spleen tissue collected from treated mice was analyzed by RT-PCR and FACS. Treatment with Herba Taraxaci induced IL-4 mRNA, and spleen from mice receiving the combined treatment (Herba Taraxaci and colchicines) showed an increased number of splenocytes staining with anti-IL-10 (46.8+/-6.80) compared to Herba Taraxaci (35.4+/-2.17) (p<0.05) or colchicine alone (26.2+/-4.47) (p<0.001). These results suggest that the Herba Taraxaci may be an effective complementary agent in the treatment of BD.
MeSH terms
AnimalsBehcet Syndrome/drug therapy*Cells, CulturedColchicine/therapeutic use*Cytokines/biosynthesis*DNA PrimersDrug Therapy, CombinationFlow CytometryInterferon-gamma/biosynthesisInterleukin-10/biosynthesisInterleukin-4/biosynthesisMaleMiceMice, Inbred ICRPhytotherapy*Plant Extracts/therapeutic usePlants, Medicinal/chemistrySpleen/cytologySpleen/drug effects
DOI
10.1016/S1567-5769(03)00071-7
PMID
12757740
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Microbiology
Journal Papers > School of Medicine / Graduate School of Medicine > Dermatology
AJOU Authors
손, 성향이, 은소이, 성낙
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