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Overexpression of c-H-ras p21 is correlated with vascular endothelial growth factor expression and neovascularization in advanced gastric carcinoma.

Kim, YB; Han, JY; Kim, TS; Kim, PS; Chu, YC
Journal of gastroenterology and hepatology, 15(12):1393-1399, 2000
Journal Title
Journal of gastroenterology and hepatology
BACKGROUND AND AIMS: ras Gene and its product (p21) have been reported to be associated with vascular endothelial growth factor (VEGF), which is one of the most important angiogenic factors, and tumor-associated angiogenesis. We tried to evaluate the correlation between the expression of c-H-ras gene product p21 and angiogenesis in advanced gastric carcinoma.

METHODS: Immunohistochemical expression of c-H-ras p21 and VEGF was examined in 49 advanced gastric adenocarcinomas. In addition, double immunohistochemical staining was performed using anti-CD34 and anti-Ki-67 antibodies, and the intratumoral microvessel densities and their endothelial proliferative labeling indices were then counted to evaluate the degree of angiogenesis.

RESULTS: The expression of c-H-ras p21 was demonstrated in 43 out of 49 gastric adenocarcinomas (87.8%). It did not correlate with histologic type, depth of invasion or metastasis. However, the degree of c-H-ras p21 expression was correlated with VEGF. In addition, the degree of c-H-ras p21 expression was correlated with increased intratumoral microvascular density and endothelial proliferative activity.

CONCLUSIONS: We suggest that c-H-ras oncogene product p21 contributes to the upregulation of tumor-associated angiogenesis by the increased production of VEGF in advanced gastric carcinomas. Therefore, treatment involving the targeting of ras oncogene could inhibit solid tumor growth by suppressing tumor-associated angiogenesis.
MeSH terms
Adenocarcinoma/*blood supply/*metabolismAdultAgedEndothelial Growth Factors/*metabolismFemaleHumansImmunohistochemistryLymphokines/*metabolismMaleMiddle AgedNeovascularization, Pathologic/*metabolismProto-Oncogene Proteins p21(ras)/*metabolismStomach Neoplasms/*metabolism/*pathologyVascular Endothelial Growth Factor AVascular Endothelial Growth Factors
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
AJOU Authors
김, 영배
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