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Reversion from precore/core promoter mutants to wild-type hepatitis B virus during the course of lamivudine therapy.

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dc.contributor.authorCho, SW-
dc.contributor.authorHahm, KB-
dc.contributor.authorKim, JH-
dc.date.accessioned2011-07-28T01:05:09Z-
dc.date.available2011-07-28T01:05:09Z-
dc.date.issued2000-
dc.identifier.issn0270-9139-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/3645-
dc.description.abstractThe effect of lamivudine administration on the evolution of precore/core promoter mutation is unknown. The aim of this study was to determine the changes of precore/core promoter sequences in chronic type B hepatitis patients treated with lamivudine. Serial sera were obtained from 11 patients before, at the beginning of, and during therapy. Serum samples were polymerase chain reaction-amplified, and nucleotide sequences of hepatitis B virus (HBV) were analyzed. At baseline, precore and core promoter mutations were found in 6 and 4 of 11 patients, respectively. A precore stop codon mutant was replaced by a wild-type virus in all 6 patients infected with precore mutant at a median treatment of 12 months (vs. before therapy; P =.011). Mutations in the core promoter appeared in only 1 of 10 patients (vs. before therapy; P =.021). However, precore and core promoter mutations appeared in 5 and 7 of 10 patients at a median treatment of 21 months, respectively. Acute exacerbation occurred after lamivudine withdrawal in 2 patients who had hepatitis B e antigen (HBeAg) loss or seroconversion. The serum remained HBeAg-negative throughout the study period, and each of 2 patients had precore wild-type virus during acute exacerbation. HBV mutants with core gene deletions are not eliminated completely during prolonged therapy in 2 patients in whom the HBV genomes had core gene deletions at baseline. In conclusion, lamivudine therapy resulted in reversion from precore/core promoter mutants to wild-type. However, mutations in the precore and core promoter region reappeared during prolonged therapy. HBeAg-negative wild-type precore hepatitis B virus could be selected after lamivudine withdrawal in patients who had HBeAg loss or seroconversion.-
dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHFemale-
dc.subject.MESHGene Deletion-
dc.subject.MESHHepatitis B e Antigens-
dc.subject.MESHHepatitis B virus-
dc.subject.MESHHepatitis B, Chronic-
dc.subject.MESHHumans-
dc.subject.MESHLamivudine-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMutation-
dc.subject.MESHPromoter Regions, Genetic-
dc.subject.MESHReverse Transcriptase Inhibitors-
dc.subject.MESHViral Core Proteins-
dc.titleReversion from precore/core promoter mutants to wild-type hepatitis B virus during the course of lamivudine therapy.-
dc.typeArticle-
dc.identifier.pmid11050070-
dc.contributor.affiliatedAuthor조, 성원-
dc.contributor.affiliatedAuthor함, 기백-
dc.contributor.affiliatedAuthor김, 진홍-
dc.type.localJournal Papers-
dc.identifier.doi10.1053/jhep.2000.19618-
dc.citation.titleHepatology (Baltimore, Md.)-
dc.citation.volume32-
dc.citation.number5-
dc.citation.date2000-
dc.citation.startPage1163-
dc.citation.endPage1169-
dc.identifier.bibliographicCitationHepatology (Baltimore, Md.), 32(5). : 1163-1169, 2000-
dc.identifier.eissn1527-3350-
dc.relation.journalidJ002709139-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
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