70 225

Cited 0 times in

Effect of transcatheter endovascular radiation with holmium-166 on neointimal formation after balloon injury in porcine coronary artery.

Authors
Kim, HS; Cho, YH; Kim, JS; Oh, YT; Kang, HJ; Chun, MS; Joh, CW; Park, CH; Park, KB; Tahk, SJ; Choi, BW
Citation
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 7(5):478-483, 2000
Journal Title
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
ISSN
1071-35811532-6551
Abstract
BACKGROUND: Neointimal formation in response to arterial injury is a major contributing element in restenosis after coronary balloon angioplasty and stenting. Endovascular irradiation has been reported to be effective in reducing restenosis. The purpose of this study was to investigate the effect of beta-emitting holmium-166 for the inhibition of neointimal formation in porcine coronary artery.



METHODS AND RESULTS: A total of 34 pigs weighing 25 to 30 kg underwent oversized balloon injury (balloon/artery ratio, 1.3:1.4) at the proximal portion of the left anterior descending and circumflex arteries. One artery was randomly assigned to receive radiation after injury. Ho-166 was left in the balloon within the delivery catheter for a period sufficient to deliver 9 Gy and 18 Gy to a depth of 1 mm from the surface of the balloon. Four weeks later, pigs were sacrificed and hearts were perfusion-fixed, followed by histopathologic analysis and planimetry for measurement of maximal intimal thickness, intimal area, and fracture length. The coronary segment of the pigs in the control group had neointimal area of 1.18+/-0.55 mm2; the pigs in the 9-Gy group had neointimal area of 0.68+/-0.40 mm2 (P<.05 vs. control); and the pigs in the 18-Gy group had neointimal area of 0.29+/-0.12 mm2 (P<.01 vs. control). The maximal intimal thickness in the 18-Gy group (0.14+/-0.11 mm) was significantly reduced compared with the maximal intimal thickness in the control group (0.48+/-0.13 mm) (P<.01).



CONCLUSIONS: Intracoronary radiation with liquid Ho-166 contained in a perfusion balloon catheter is feasible and effective in reducing neointimal formation after coronary overstretch injury in pigs. Therefore intracoronary irradiation on the injured segment may further reduce restenosis after balloon injury.
MeSH terms
AnimalsArteries/pathology/radiation effects*Balloon DilationCoronary Disease/pathology/radiotherapyCoronary Vessels/injuries/*pathology/radiation effectsHeart CatheterizationHolmium/administration & dosage/*therapeutic useRadioisotopes/administration & dosage/*therapeutic useRadiotherapy DosageRecurrenceSwineTunica Intima/*pathology/radiation effects
PMID
11083197
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Cardiology
Journal Papers > School of Medicine / Graduate School of Medicine > Radiation Oncology
Journal Papers > School of Medicine / Graduate School of Medicine > Nuclear Medicine & Molecular Imaging
AJOU Authors
김, 한수오, 영택강, 해진전, 미선조, 철우박, 찬희탁, 승제최, 병일
Files in This Item:
Full-Text Not Available.txtDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse