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Two-spotted spider mite (Tetranychus urticae): an important allergen in asthmatic non-farmers symtomatic in summer and fall months.

Authors
Jee, YK; Park, HS; Kim, HY; Park, JS; Lee, KY; Kim, KY; Kim, YK; Cho, SH; Min, KU; Kim, YY
Citation
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 84(5):543-548, 2000
Journal Title
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
ISSN
1081-12061534-4436
Abstract
BACKGROUND: The Tetranychus urticae (two-spotted spider mite, TSM) is a spider mite commonly found on fruit trees, herbaceous plants, and greenhouse flowers.



OBJECTIVE: To evaluate the clinical significance of TSM-derived allergens in non-farmers with asthma living around pear orchards, and to assess the allergenic relationship with house dust mite.



METHODS: Skin prick tests with TSM were performed in 50 asthmatic non-farmers living around pear orchards. The serum TSM-specific IgE was measured in the 16 asthmatics with a positive skin response to TSM. To diagnose TSM-induced asthma, specific bronchial challenges with TSM were performed in the 16 asthmatics. ELISA inhibition tests were performed to assess the allergenic cross-reactivity with house dust mites.



RESULTS: Ten of the 16 asthmatics with positive skin responses to TSM showed a significant bronchoconstriction following inhalation of TSM. Eight of the ten TSM-induced asthmatics had high serum TSM-specific IgE and one showed a positive skin response only to TSM. Their asthmatic symptoms were aggravated seasonally, especially in summer and early fall. On ELISA inhibition tests, partial inhibitions with D. pteronyssinus antigens were noted in sera from five asthmatics with positive skin responses to both TSM and D. pteronyssinus, although no inhibition was noted in serum from an asthmatic with a positive skin response only to TSM.



CONCLUSION: Tetranychus urticae may be an important allergen in asthmatic non-farmers living around pear orchards and TSM extracts contain species-specific allergens as well as commonly shared allergens with house dust mite.
MeSH terms
AdolescentAdultAllergens/bloodAnimalsAsthma/blood/immunologyBronchial Provocation TestsDose-Response Relationship, ImmunologicFemaleFruit/parasitologyHumansMaleMiddle Aged*Mites/immunologySeasonsSkin Tests
PMID
10831010
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
AJOU Authors
박, 해심
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