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Hypersensitivity pneumonitis caused by Fusarium napiforme in a home environment.

Authors
Lee, SK; Kim, SS; Nahm, DH; Park, HS; Oh, YJ; Park, KJ; Kim, SO; Kim, SJ
Citation
Allergy, 55(12):1190-1193, 2000
Journal Title
Allergy
ISSN
0105-45381398-9995
Abstract
BACKGROUND: We report a case of hypersensitivity pneumonitis (HP) in a 17-year-old male student caused by Fusarium napiforme found in his home environment.



METHODS: The patient was diagnosed according to history, chest radiograph, spirometry, high-resolution chest CT, and transbronchial lung biopsy. To identify the causative agent, cultured aeromolds were collected by the open-plate method. From the main fungi cultured, fungal antigens were prepared, and immunoblot analysis with the patient's serum and each fungal antigen was performed.



RESULTS: Five fungal species were isolated from the patient's home. Immunoblotting analysis with the patient's serum demonstrated more than 10 IgG-binding fractions to F. napiforme extract only, while little binding was noted with the other fungal antigens.



CONCLUSIONS: We should be aware that HP may be caused by F. napiforme in the home environment.
MeSH terms
AdolescentAir Pollution, Indoor/*analysisAlveolitis, Extrinsic Allergic/immunology/*microbiologyAntibodies, Fungal/immunologyAntigens, Fungal/immunologyColony Count, MicrobialElectrophoresis, Polyacrylamide GelFusarium/immunology/*isolation & purificationHousingHumansImmunoblottingMaleMycoses/immunology/*microbiology
PMID
11117278
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
AJOU Authors
김, 선신남, 동호박, 해심
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