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Human neural stem cells can migrate, differentiate, and integrate after intravenous transplantation in adult rats with transient forebrain ischemia.

Authors
Chu, K; Kim, M; Jeong, SW; Kim, SU; Yoon, BW
Citation
Neuroscience letters, 343(2):129-133, 2003
Journal Title
Neuroscience letters
ISSN
0304-39401872-7972
Abstract
Intraparenchymally transplanted rodent-origin neural and human-origin mesenchymal stem cells migrate and differentiate in neurological diseases. By intravenously injecting human neural stem cells, we showed that transplanted human neural stem cells migrate to the damaged hippocampus, proliferate and differentiate into mature neurons and astrocytes in the adult rat brain with transient forebrain ischemia. We also demonstrated the migratory course of implanted human neural stem cells after intravenous injection. Our findings show that transplanted human neural stem cells differentiate into mature neurons to replace lost neural cells in the adult hippocampus with human-rat neural chimeras.
MeSH terms
AnimalsBrain Ischemia/physiopathology*Cell Differentiation*Cell Movement*Glial Fibrillary Acidic Protein/metabolismHippocampus/anatomy & histologyHippocampus/metabolismHumansImmunohistochemistryInjections, Intravenous/methodsInjections, Intraventricular/methodsMaleNerve Tissue Proteins/metabolismNeurofilament Proteins/metabolismRatsRats, Sprague-DawleyStem Cell Transplantation*Stem Cells/cytology*Time FactorsVimentin/metabolismbeta-Galactosidase/metabolism
PMID
12759181
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
AJOU Authors
김, 승업
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