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Amyloid beta peptide-induced corpus callosum damage and glial activation in vivo.

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dc.contributor.authorRyu, JK-
dc.contributor.authorKim, SU-
dc.contributor.authorMcLarnon, JG-
dc.date.accessioned2011-07-29T04:21:05Z-
dc.date.available2011-07-29T04:21:05Z-
dc.date.issued2003-
dc.identifier.issn0959-4965-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/3680-
dc.description.abstractThe effects of stereotaxic injection of amyloid beta-peptide (Abeta1-42) into rat brain to induce white matter damage have been studied. Administration of 1 nmol Abeta1-42 into corpus callosum resulted in considerable damage to axons as evidenced by the loss of neurofilament-immunoreactive (NF-ir) fibers 6 h and 3 and 7 days post-injection. Significant damage was also evident to myelin (using Luxol fast blue myelin staining) and oligodendrocytes (using CC1 immunocytochemistry); in the latter case marked caspase-3 immunoreactivity was evident in oligodendrocytes. Additionally, the numbers of GFAP-ir astrocytes and OX-42/OX-6-ir microglia were markedly increased following Abeta1-42 injection. These results suggest that Abeta plays an important pathophysiological role in white matter damage and that inflammatory responses may contribute to Abeta-induced demyelination and oligodendrocyte injury in corpus callosum. Loss of function of cells in corpus callosum could provide a potential new model for the study of white matter damage in Alzheimer's disease.-
dc.language.isoen-
dc.subject.MESHAmyloid beta-Peptides-
dc.subject.MESHAnimals-
dc.subject.MESHAstrocytes-
dc.subject.MESHAxons-
dc.subject.MESHColoring Agents-
dc.subject.MESHCorpus Callosum-
dc.subject.MESHGlial Fibrillary Acidic Protein-
dc.subject.MESHGliosis-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHMacrophage Activation-
dc.subject.MESHMale-
dc.subject.MESHMicroscopy, Fluorescence-
dc.subject.MESHMyelin Sheath-
dc.subject.MESHNerve Fibers-
dc.subject.MESHNeuroglia-
dc.subject.MESHOligodendroglia-
dc.subject.MESHPeptide Fragments-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHStereotaxic Techniques-
dc.titleAmyloid beta peptide-induced corpus callosum damage and glial activation in vivo.-
dc.typeArticle-
dc.identifier.pmid12960758-
dc.identifier.urlhttp://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0959-4965&volume=14&issue=11&spage=1429-
dc.contributor.affiliatedAuthor김, 승업-
dc.type.localJournal Papers-
dc.identifier.doi10.1097/01.wnr.0000086097.47480.a0-
dc.citation.titleNeuroreport-
dc.citation.volume14-
dc.citation.number11-
dc.citation.date2003-
dc.citation.startPage1429-
dc.citation.endPage1433-
dc.identifier.bibliographicCitationNeuroreport, 14(11). : 1429-1433, 2003-
dc.identifier.eissn1473-558X-
dc.relation.journalidJ009594965-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
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