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Neuroprotective effects of pyruvate in the quinolinic acid rat model of Huntington's disease.v

Authors
Ryu, JK; Kim, SU; McLarnon, JG
Citation
Experimental neurology, 183(2):700-704, 2003
Journal Title
Experimental neurology
ISSN
0014-48861090-2430
Abstract
The neuroprotective effects of pyruvate, the end metabolite of glycolysis, were studied in an animal model of Huntington's disease (HD). Intrastriatal injection of quinolinic acid (QA) caused widespread damage to rat striatum as determined from cresyl violet staining and immunohistochemical analysis. Intraperitoneal administration of pyruvate at doses of 500-1000 mg/kg significantly reduced striatal lesions induced by QA. A lower pyruvate concentration of 250 mg/kg was not protective; however, quadruple applications at this dosage was effective in reducing lesion volumes. The protective effects of pyruvate were found over a range of times, from application at the time of QA injection to 1 h post-administration; however, no protection was conferred if pyruvate was applied 30 min prior to QA injection or 3 h post-administration. We also found pyruvate protects different types of striatal neurons against QA toxicity including GABAergic projection neurons, cholinergic interneurons and NADPH-diaphorase interneurons. These results suggest that pyruvate may be effective in reducing neuronal damage in HD.
MeSH terms
AnimalsCorpus Striatum/drug effectsCorpus Striatum/pathologyDisease Models, AnimalDose-Response Relationship, DrugDrug Administration RoutesHuntington Disease/chemically inducedHuntington Disease/drug therapy*Huntington Disease/pathologyInterneurons/drug effectsInterneurons/pathologyMaleNeurons/drug effectsNeurons/pathologyNeuroprotective Agents/therapeutic use*Pyruvic Acid/therapeutic use*Quinolinic Acid*RatsRats, Sprague-DawleyTime FactorsTreatment Outcome
PMID
14552912
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
AJOU Authors
김, 승업
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