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Involvement of Fc(epsilon)R1beta gene polymorphisms in susceptibility to atopy in Korean children with asthma.
DC Field | Value | Language |
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dc.contributor.author | Kim, ES | - |
dc.contributor.author | Kim, SH | - |
dc.contributor.author | Kim, KW | - |
dc.contributor.author | Park, HS | - |
dc.contributor.author | Shin, ES | - |
dc.contributor.author | Lee, JE | - |
dc.contributor.author | Sohn, MH | - |
dc.contributor.author | Kim, KE | - |
dc.date.accessioned | 2010-12-01T02:48:29Z | - |
dc.date.available | 2010-12-01T02:48:29Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0340-6199 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/368 | - |
dc.description.abstract | INTRODUCTION: IgE-dependent activation of mast cells and basophils through the high-affinity IgE receptor (Fc(epsilon)R1) is involved in the pathogenesis of allergen-induced immune responsiveness in atopic disease including bronchial asthma.
MATERIALS AND METHODS: We genotyped 650 children for allelic determinants at two polymorphic sites, -109T/C and E237G, in the Fc(epsilon)R1beta gene by SNP-IT assays using the SNP stream 25K system. RESULTS: Distributions of the genotype and allele frequencies of Fc(epsilon)R1beta -109T/C and E237G polymorphisms were significantly associated with atopy (P < 0.05) and elevated serum IgE levels. However, differences in the E237G polymorphism did not reach statistical significance after adjustment for multiple comparisons. The genotypes TC or CC at -109T/C were associated with decreased forced expiratory flow(25-75%) in children with asthma (P < 0.05), but this did not reach statistical significance after correction for multiple comparisons. In addition, haplotype 1 (T-A) was associated with atopy susceptibility (P = 0.0069). Analysis of genotype distributions of haplotypes demonstrated a significantly lower PC(20) for homozygous -/- diploids compared with homozygous Ht1/Ht1 (P = 0.0261). CONCLUSION: Polymorphisms in the Fc(epsilon)R1beta gene confer susceptibility to atopy in Korean children and may have a disease-modifying effect on airways of asthmatic patients. | - |
dc.language.iso | en | - |
dc.title | Involvement of Fc(epsilon)R1beta gene polymorphisms in susceptibility to atopy in Korean children with asthma. | - |
dc.type | Article | - |
dc.identifier.pmid | 19288130 | - |
dc.contributor.affiliatedAuthor | 김, 승현 | - |
dc.contributor.affiliatedAuthor | 박, 해심 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1007/s00431-009-0960-x | - |
dc.citation.title | European journal of pediatrics | - |
dc.citation.volume | 168 | - |
dc.citation.number | 12 | - |
dc.citation.date | 2009 | - |
dc.citation.startPage | 1483 | - |
dc.citation.endPage | 1490 | - |
dc.identifier.bibliographicCitation | European journal of pediatrics, 168(12). : 1483-1490, 2009 | - |
dc.identifier.eissn | 1432-1076 | - |
dc.relation.journalid | J003406199 | - |
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