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Hepatitis B virus X protein induced expression of the Nur77 gene.

DC Field Value Language
dc.contributor.authorLee, MO-
dc.contributor.authorKang, HJ-
dc.contributor.authorCho, H-
dc.contributor.authorShin, EC-
dc.contributor.authorPark, JH-
dc.contributor.authorKim, SJ-
dc.date.accessioned2011-08-08T05:03:51Z-
dc.date.available2011-08-08T05:03:51Z-
dc.date.issued2001-
dc.identifier.issn0006-291X-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/3703-
dc.description.abstractHepatitis B virus (HBV) X protein (HBx) plays an essential role in development of HBV-associated hepatocellular carcinoma (HCC). Recently, we reported that HBx induces Fas Ligand (FasL) expression, which may help HCC cells to evade host-immune surveillance. The aim of this study was to investigate the role of HBx in expression of Nur77, an orphan nuclear receptor implicated in the upregulation of FasL. When Chang X-34 expressing HBx under the control of a doxycycline-inducible promoter was examined, induction of Nur77 was observed following HBx expression. Blocking of Nur77 function by introduction of an antisense or a dominant negative mutant Nur77 significantly inhibited the induction of FasL, indicating that Nur77 plays critical roles in FasL expression. Further, a high-level expression of transcripts and DNA binding of Nur77 were observed in the HBV-integrated cell lines established from HCC patients that express HBx. These results suggested that Nur77 may contribute to leading the HBx-induced Fas/FasL signaling pathway which eliminates invading Fas-expressing lymphocytes.-
dc.language.isoen-
dc.subject.MESHCarcinoma, Hepatocellular-
dc.subject.MESHDNA-Binding Proteins-
dc.subject.MESHFas Ligand Protein-
dc.subject.MESHHepatitis B-
dc.subject.MESHHepatitis B virus-
dc.subject.MESHHumans-
dc.subject.MESHLiver Neoplasms-
dc.subject.MESHMembrane Glycoproteins-
dc.subject.MESHMutation-
dc.subject.MESHNuclear Receptor Subfamily 4, Group A, Member 1-
dc.subject.MESHOligonucleotides, Antisense-
dc.subject.MESHPromoter Regions, Genetic-
dc.subject.MESHRNA, Messenger-
dc.subject.MESHReceptors, Cytoplasmic and Nuclear-
dc.subject.MESHReceptors, Steroid-
dc.subject.MESHTrans-Activators-
dc.subject.MESHTranscription Factors-
dc.subject.MESHTranscriptional Activation-
dc.subject.MESHTransfection-
dc.subject.MESHTumor Cells, Cultured-
dc.titleHepatitis B virus X protein induced expression of the Nur77 gene.-
dc.typeArticle-
dc.identifier.pmid11700033-
dc.identifier.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0006-291X(01)95910-8-
dc.contributor.affiliatedAuthor조, 혜성-
dc.type.localJournal Papers-
dc.identifier.doi10.1006/bbrc.2001.5910-
dc.citation.titleBiochemical and biophysical research communications-
dc.citation.volume288-
dc.citation.number5-
dc.citation.date2001-
dc.citation.startPage1162-
dc.citation.endPage1168-
dc.identifier.bibliographicCitationBiochemical and biophysical research communications, 288(5). : 1162-1168, 2001-
dc.identifier.eissn1090-2104-
dc.relation.journalidJ00006291X-
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Journal Papers > School of Medicine / Graduate School of Medicine > Biochemistry & Molecular Biology
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