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Mixture of N-carbamoyl-L-glutamate plus L-arginine can protect rats with liver cirrhosis from acute ammonia intoxication.

DC Field Value Language
dc.contributor.authorKim, WH-
dc.contributor.authorPark, H-
dc.contributor.authorYun, C-
dc.contributor.authorCho, H-
dc.contributor.authorKim, S-
dc.contributor.authorPaik, WK-
dc.contributor.authorJeon, SH-
dc.contributor.authorLee, JH-
dc.date.accessioned2011-08-17T04:48:07Z-
dc.date.available2011-08-17T04:48:07Z-
dc.date.issued2001-
dc.identifier.issn0168-8278-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/3748-
dc.description.abstractBACKGROUND/AIMS: We earlier reported that N-carbamoyl-L-glutamate (CG) plus L-arginine (Arg) protected normal and 70% hepatectomized rats from intoxication by a lethal or sub-lethal dose of ammonium acetate, respectively. In the present study, the protective effect of these compounds on cirrhotic rats was assessed.



METHODS: CG plus Arg were administered prior to the injection of a sub-lethal dose of ammonium acetate into dimethylnitrosamine-induced cirrhotic rats. Control rats were given phosphate-buffered saline (PBS) instead of the mixture. The behavior of the rats was monitored until the time of sacrifice. Blood ammonia level, blood urea nitrogen (BUN) and liver carbamoylphosphate synthetase I (CPS I) activity were determined.



RESULTS: Pretreatment of rats with the mixture of CG plus Arg could significantly lower the blood ammonia level (P<0.05), increase the activity of CPS I (P<0.05), improve abnormal behavior associated with ammonia intoxication (P<0.05), and increase BUN (P<0.05), as compared with the PBS-injected control group. There were significantly close correlations between (1) the increase of CPS I activity; (2) the improvement of abnormal behavior; (3) the increase of BUN; and (4) the decrease of the blood ammonia level.



CONCLUSIONS: A mixture of CG plus Arg could protect rats with liver cirrhosis from acute ammonia intoxication.
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dc.language.isoen-
dc.subject.MESHAcetates-
dc.subject.MESHAcute Disease-
dc.subject.MESHAmmonia-
dc.subject.MESHAnimals-
dc.subject.MESHArginine-
dc.subject.MESHBehavior, Animal-
dc.subject.MESHCarbamoyl-Phosphate Synthase (Ammonia)-
dc.subject.MESHDimethylnitrosamine-
dc.subject.MESHDrug Synergism-
dc.subject.MESHGlutamates-
dc.subject.MESHLiver Cirrhosis-
dc.subject.MESHMale-
dc.subject.MESHPoisoning-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHTime Factors-
dc.titleMixture of N-carbamoyl-L-glutamate plus L-arginine can protect rats with liver cirrhosis from acute ammonia intoxication.-
dc.typeArticle-
dc.identifier.pmid11738098-
dc.identifier.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0168-8278(01)00199-4-
dc.contributor.affiliatedAuthor김, 욱환-
dc.contributor.affiliatedAuthor조, 혜성-
dc.contributor.affiliatedAuthor백, 운기-
dc.contributor.affiliatedAuthor전, 성후-
dc.contributor.affiliatedAuthor이, 재호-
dc.type.localJournal Papers-
dc.citation.titleJournal of hepatology-
dc.citation.volume35-
dc.citation.number6-
dc.citation.date2001-
dc.citation.startPage719-
dc.citation.endPage725-
dc.identifier.bibliographicCitationJournal of hepatology, 35(6). : 719-725, 2001-
dc.identifier.eissn1600-0641-
dc.relation.journalidJ001688278-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
Journal Papers > School of Medicine / Graduate School of Medicine > Biochemistry & Molecular Biology
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