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Reactive oxygen species mediate A beta(25-35)-induced activation of BV-2 microglia.

Authors
Kang, J; Park, EJ; Jou, I; Kim, JH; Joe, EH
Citation
Neuroreport, 12(7):1449-1452, 2001
Journal Title
Neuroreport
ISSN
0959-49651473-558X
Abstract
Microglial activation induced by beta-amyloid (A beta) is an important cellular response in the pathogenesis of Alzheimer's disease (AD). In this study, we show that reactive oxygen species (ROS) play a role as signaling molecules for the activation of NF-kappaB and induction of IL-1beta mRNA expression in A beta(25-35)-treated murine microglia BV-2 cells. ROS scavengers such catalase and superoxide dismutase (SOD) mimetics obviously reduced activation of NF-kappaB and the elevated level of IL-1beta transcripts induced by A beta(25-35). In addition, the A beta(25-35)-induced NF-kappaB activation and IL-1beta expression were suppressed by blockers of the ROS generating enzymes such as NADPH oxidase, cyclooxygenase, and lipoxygenase. These data suggest that ROS mediate A beta-induced microglial activation.
MeSH terms
Alzheimer Disease/metabolism*Alzheimer Disease/pathologyAlzheimer Disease/physiopathologyAmyloid beta-Peptides/metabolismAmyloid beta-Peptides/pharmacology*AnimalsBrain/metabolism*Brain/pathologyBrain/physiopathologyCell Line, Transformed/drug effectsCell Line, Transformed/metabolismCell Line, Transformed/pathologyEnzyme Inhibitors/pharmacologyFree Radical Scavengers/pharmacologyGene Expression Regulation/drug effectsGene Expression Regulation/physiologyGliosis/chemically inducedGliosis/metabolismGliosis/physiopathologyInterleukin-1/genetics*Lipoxygenase/drug effectsLipoxygenase/metabolismMiceMicroglia/drug effects*Microglia/metabolismMicroglia/pathologyNADPH Oxidase/drug effectsNADPH Oxidase/metabolismNF-kappa B/drug effectsNF-kappa B/metabolism*Peptide Fragments/metabolismPeptide Fragments/pharmacology*Prostaglandin-Endoperoxide Synthases/drug effectsProstaglandin-Endoperoxide Synthases/metabolismRNA, Messenger/drug effectsRNA, Messenger/metabolismReactive Oxygen Species/metabolism*Signal Transduction/physiology
PMID
11388427
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pharmacology
AJOU Authors
주, 일로조, 은혜
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