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Dichotomy between Tc-99m MDP bone scan and fluorine-18 fluorodeoxyglucose coincidence detection positron emission tomography in patients with non-Hodgkin's lymphoma.

Lee, J; Park, CH; Kim, HC; Kim, HS
Clinical nuclear medicine, 25(7):532-535, 2000
Journal Title
Clinical nuclear medicine
The authors report two cases of non-Hodgkin's lymphoma that were evaluated not only by conventional staging work-up but also additional Tc-99m MDP bone scans and fluorine-18 fluorodeoxyglucose (F-18 FDG) coincidence detection (CoDe) positron emission tomographic (PET) imaging. There were discordant results between the Tc-99m MDP bone scans and F-18 FDG CoDe PET. In the first case, the bone marrow biopsy was positive, and F-18 FDG CoDe PET was consistent with a malignancy, but the findings of the Tc-99m MDP bone scintiscan were negative. In the second case, the bone marrow biopsy was negative, but F-18 FDG CoDe PET revealed focal skeletal involvement, which improved markedly on the follow-up study after chemotherapy. If skeletal involvement has a focal distribution and is confined to the marrow cavity, both bone marrow biopsy and bone scintigraphy can be falsely negative. In this situation, F-18 FDG PET is useful and revealing.
MeSH terms
AdultBone Marrow Neoplasms/*radionuclide imagingFalse Negative ReactionsFemaleFluorodeoxyglucose F18/*diagnostic useHumansLymphoma, Non-Hodgkin/*radionuclide imagingMaleMiddle AgedRadiopharmaceuticals/*diagnostic useTechnetium Tc 99m Medronate/*diagnostic use*Tomography, Emission-Computed
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Hematology-Oncology
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
Journal Papers > School of Medicine / Graduate School of Medicine > Nuclear Medicine & Molecular Imaging
AJOU Authors
박, 찬희김, 효철김, 현수
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