Identification of the human homologue of mouse KIF4, a kinesin superfamily motor protein.
Oh, S; Hahn, H; Torrey, TA; Shin, H; Choi, W; Lee, YM; Morse, HC; Kim, W
Biochimica et biophysica acta, 1493(1-2):219-224, 2000
Biochimica et biophysica acta
A combination of RT-PCR with cDNA library screening led to the identification of the human homologue of murine KIF4 (mKIF4), a microtubule-based motor protein. The nucleotide sequence of human KIF4 (hKIF4) comprised part of the 5' untranslated region (UTR), a long open reading frame (ORF) encoding 1232 amino acids, and the entire 3' UTR. Homologies with mKIF4 were 82% and 85% for nucleotides and amino acids, respectively. A single transcript of 5. 0 kb was highly expressed in hematopoietic tissues including fetal liver, spleen, and thymus, and adult thymus and bone marrow. Comparison of the ORF with that of mKIF4 revealed some dissimilarities in the putative cargo binding domain which might affect binding specificities.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
Total Visit :2,391,514
Total Download :1,019,149
Today View :136
Ajou University Medical Information & Media Center 164 Worldcup-ro Yeongtong-gu Suwon 16499 Korea / TEL : 031-219-5312 / FAX : 031-219-5314 Copyright (c) Ajou University Medical Information & Media Center All Rights Reserved. AJOU Open Repository는 국립중앙도서관 OAK 보급사업으로 구축되었습니다.