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Structure-activity relationship study of asiatic acid derivatives against beta amyloid (A beta)-induced neurotoxicity.

Authors
Jew, SS; Yoon, CH; Lim, DY; Kim, H; Mook-Jung, I; Jung, MW; Choi, H; Jung, YH; Park, HG
Citation
Bioorganic & medicinal chemistry letters, 10(2):119-121, 2000
Journal Title
Bioorganic & medicinal chemistry letters
ISSN
0960-894X1464-3405
Abstract
8 Semi-synthetic derivatives of asiatic acid were prepared and their protective effect against A beta-induced neurotoxicity was evaluated. Among them, asiatic acid (2), and 4, 16 showed 97, 92 and 87% of protective effect, respectively.
MeSH terms
Alzheimer Disease/drug therapyAmyloid beta-Peptides/antagonists & inhibitors/*pharmacologyCell Death/drug effectsCell LineHumansMolecular StructureNeuroprotective Agents/chemical synthesis/*pharmacologyPentacyclic TriterpenesPeptide Fragments/antagonists & inhibitors/*pharmacologyPlants, Medicinal/chemistryStructure-Activity RelationshipTriterpenes/chemistry/*pharmacology
PMID
10673093
Appears in Collections:
Journal Papers > Research Organization > Brain Disease Research Center
Journal Papers > Research Organization > Institute for Medical Sciences
AJOU Authors
묵, 인희정, 민환
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