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Staurosporine induces de novo synthesis of prostaglandin H synthase-2 in rat alveolar macrophages.

Authors
Moon, CK; Lee, SH; Kim, JY; Kim, MJ; Lee, JY; Moon, CH
Citation
Life sciences, 57(6):571-578, 1995
Journal Title
Life sciences
ISSN
0024-32051879-0631
Abstract
This study was initiated to investigate the possible involvement of prostaglandin H synthase in the staurosporine-induced prostaglandin production. The time course of prostaglandin H synthase activity in macrophages treated with staurosporine (20 nM) showed that the maximum activity was reached in 20 h. The stimulatory effect of staurosporine on thromboxane B2 production was maximum at 50 nM staurosporine and this effect was reversed at higher concentrations. Immunoprecipitation of 35S-labeled enzyme using an antibody specific for prostaglandin H synthase-2 paralleled the changes in enzyme activity. These results indicate that increased de novo synthesis of prostaglandin H synthase-2 is largely, if not solely, responsible for staurosporine-stimulated prostaglandin production in macrophages.
MeSH terms
Alkaloids/*pharmacologyAnimalsDose-Response Relationship, DrugMacrophages, Alveolar/*drug effects/metabolismPrecipitin TestsProstaglandin-Endoperoxide Synthases/biosynthesis/*drug effectsRatsRats, Sprague-DawleyStaurosporineThromboxane B2/biosynthesis
PMID
7623624
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
AJOU Authors
이, 수환문, 창현
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