61 172

Cited 0 times in

Pharmacokinetic changes of methotrexate after intravenous administration to streptozotocin-induced diabetes mellitus rats.

Authors
Park, JM; Moon, CH; Lee, MG
Citation
Research communications in molecular pathology and pharmacology, 93(3):343-352, 1996
Journal Title
Research communications in molecular pathology and pharmacology
ISSN
1078-0297
Abstract
The pharmacokinetic changes of methotrexate (MTX) were investigated after 1-min intravenous (iv) administration of MTX, 8 mg/kg, to the control and the streptozotocin-induced diabetes mellitus (SIDM) rats. After 1-min iv infusion of MTX, plasma concentrations of MTX declined polyexponentially for both groups of rats. In the SIDM rats, the plasma concentrations of MTX were significantly lower up to 5 min, however, significantly higher from 60 min than those in the control rats. In the SIDM rats, the volume of distribution at steady state was significantly higher (1010 versus 265 ml/kg) than that in the control rats, and this was due to the significantly increased unbound fraction of MTX (73.0 versus 58.1%) in serum of SIDM rats. This resulted in a significantly increased mean residence time (53.2 versus 13.8 min) in the SIDM rats. All 12 control rats survived until sacrificed (24 hr), however, 6 out of 15 SIDM rats died within 6 h after iv administration of MTX, suggesting that the iv doses of MTX in diabetes mellitus patients may need to be modified if the present rat data could be extrapolated to human beings.
MeSH terms
AnimalsBlood Glucose/drug effectsDiabetes Mellitus, Experimental/blood/*metabolismInfusions, IntravenousMaleRatsRats, Sprague-Dawley
PMID
8896045
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
AJOU Authors
문, 창현
Files in This Item:
full-text not available.txtDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse