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Differential expression of TIS21 and TIS1 genes in the various organs of Balb/c mice, thymic carcinoma tissues and human cancer cell lines.

DC Field Value Language
dc.contributor.authorLim, IK-
dc.contributor.authorLee, MS-
dc.contributor.authorLee, SH-
dc.contributor.authorKim, NK-
dc.contributor.authorJou, I-
dc.contributor.authorSeo, JS-
dc.contributor.authorPark, SC-
dc.date.accessioned2011-08-19T05:25:12Z-
dc.date.available2011-08-19T05:25:12Z-
dc.date.issued1995-
dc.identifier.issn0171-5216-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/3816-
dc.description.abstractAs a part of a series of investigations on the functions of TIS21 and TIS1 genes, we measured in vivo 12-O-tetradecanoylphorbol-13-acetate (TPA) inducibility of primary response genes (TIS21, TIS8 and TIS1) in the Balb/c mice and the changes of TIS gene expression in thymic carcinoma tissues and A549 and NCIH69 human lung cancer cell lines. In vivo induction of the TIS genes (TIS21, -8 and -1) by intraperitoneal injection of TPA was dramatic only at the needle contact site, i.e. in the abdominal muscle, not in the thigh muscle. Expression of TIS21 and TIS1 in the Balb/c mice thymus, lung, stomach and spleen was very strong (Lim IK et al. 1994a), regardless of TPA injection. Thymic carcinoma tissues developed in SV40-T-antigen-containing transgenic mice did not express TIS21 and TIS1, and expressed TIS8 weakly. Interestingly, induction of TIS21 expression was obliterated in the human lung cancer cells; A549 cells completely lost the ability to express TIS21 after a combined treatment of TPA and cycloheximide. We also measured the induction of TIS genes by TPA and/or cycloheximide in Raw264.7 mouse macrophage cells and U937 human histiocytic lymphoma cells. However, the induction profile was quite different; repressed and deregulated expression in the U937 cells as compared to rapid and transient induction of TIS genes in the Raw264.7 cells. These data may suggest a repressed expression of TIS21 and TIS1 in the cancer tissues and cells derived from the organs that constitutively express TIS21 in mice and in human cancer cells.-
dc.language.isoen-
dc.subject.MESHAnimals-
dc.subject.MESHGene Expression Regulation-
dc.subject.MESHGenes, Tumor Suppressor-
dc.subject.MESHHumans-
dc.subject.MESHImmediate-Early Proteins-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred BALB C-
dc.subject.MESHNeoplasms-
dc.subject.MESHProteins-
dc.subject.MESHTetradecanoylphorbol Acetate-
dc.subject.MESHThymus Neoplasms-
dc.subject.MESHTumor Cells, Cultured-
dc.subject.MESHTumor Suppressor Proteins-
dc.titleDifferential expression of TIS21 and TIS1 genes in the various organs of Balb/c mice, thymic carcinoma tissues and human cancer cell lines.-
dc.typeArticle-
dc.identifier.pmid7768965-
dc.contributor.affiliatedAuthor임, 인경-
dc.contributor.affiliatedAuthor이, 명숙-
dc.contributor.affiliatedAuthor주, 일로-
dc.type.localJournal Papers-
dc.citation.titleJournal of cancer research and clinical oncology-
dc.citation.volume121-
dc.citation.number5-
dc.citation.date1995-
dc.citation.startPage279-
dc.citation.endPage284-
dc.identifier.bibliographicCitationJournal of cancer research and clinical oncology, 121(5). : 279-284, 1995-
dc.identifier.eissn1432-1335-
dc.relation.journalidJ001715216-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Biochemistry & Molecular Biology
Journal Papers > School of Medicine / Graduate School of Medicine > Pharmacology
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