8 249

Cited 0 times in

Biological methylation of myelin basic protein: enzymology and biological significance.

Authors
Kim, S; Lim, IK; Park, GH; Paik, WK
Citation
The international journal of biochemistry & cell biology, 29(5):743-751, 1997
Journal Title
The international journal of biochemistry & cell biology
ISSN
1357-27251878-5875
Abstract
Myelin is a membrane characteristic of the nervous tissue and functions as an insulator to increase the velocity of the stimuli being transmitted between a nerve cell body and its target. Myelin isolated from human and bovine nervous tissue is composed of approximately 80% lipid and 20% protein, and 30% of the protein fraction constitutes myelin basic protein (MBP). MBP has an unusual amino acid at Res-107 as a mixture of NG-monomethylarginine and NG, N'G-dimethylarginine. The formation of these methylarginine derivatives is catalysed by one of the subtypes of protein methylase I, which specifically methylates Res-107 of this protein. Evidence is presented to demonstrate an involvement of this biological methylation in the integrity and maintenance of myelin.
MeSH terms
AnimalsBrain/enzymologyHumansMethylationMultiple Sclerosis/metabolismMyelin Basic Proteins/*metabolismMyelin Sheath/physiologyProtein-Arginine N-Methyltransferases/metabolism
PMID
9251242
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Biochemistry & Molecular Biology
AJOU Authors
임, 인경백, 운기
Full Text Link
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse