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Protection of 5alpha-dihydrotestosterone against TGF-beta-induced apoptosis in FaO cells and induction of mitosis in HepG2 cells.

Authors
Lim, IK; Joo, HJ; Choi, KS; Sueoka, E; Lee, MS; Ryu, MS; Fujiki, H
Citation
International journal of cancer, 72(2):351-355, 1997
Journal Title
International journal of cancer
ISSN
0020-71361097-0215
Abstract
Administration of TGF-beta1 to both FaO and HepG2 cells significantly induced apoptosis, particularly in FaO cells. Degradation of genomic DNA in FaO cells was rapidly induced by treatment with TGF-beta1 (5 ng/ml) for only 4 hr. 5alpha-dihydrotestosterone (DHT, 25 nM) alone did not affect any significant changes in cell viability and in nuclei of FaO cells; however, pre-treatment with DHT protected genomic DNA degradation induced by TGF-beta1 for 14 hr. Simultaneous treatment with DHT plus TGF-beta1 (D + T) inhibited TGF-beta-induced apoptosis by approximately 50% in FaO cells. On the other hand, D + T treatment increased mitosis in actively growing HepG2 cells. Thus, it is reasonable to conclude that DHT gives growth advantage to hepatocellular-carcinoma cells by inhibiting TGF-beta-induced DNA fragmentation in FaO cells and by inducting mitosis in HepG2 cells.
MeSH terms
AnimalsApoptosis/*drug effectsDihydrotestosterone/*pharmacologyDrug InteractionsHumansMitosis/*drug effectsRatsSpecies SpecificityTransforming Growth Factor beta/*pharmacologyTumor Cells, Cultured
DOI
10.1002/(SICI)1097-0215(19970717)72:2%3C351::AID-IJC25%3E3.0.CO;2-H
PMID
9219845
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
Journal Papers > School of Medicine / Graduate School of Medicine > Biochemistry & Molecular Biology
AJOU Authors
임, 인경주, 희재최, 경숙이, 명숙
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