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Expression of thymidylate synthase in gastric cancer patients treated with 5-fluorouracil and doxorubicin-based adjuvant chemotherapy after curative resection.

Authors
Choi, J; Lim, H; Nam, DK; Kim, HS; Cho, DY; Yi, JW; Kim, HC; Cho, YK; Kim, MW; Joo, HJ; Lee, KB; Kim, KB
Citation
British journal of cancer, 84(2):186-192, 2001
Journal Title
British journal of cancer
ISSN
0007-09201532-1827
Abstract
We evaluated the expression of thymidylate synthase (TS) in locally advanced gastric cancer patients treated with adjuvant chemotherapy after curative resection and investigated the association between TS expression and clinicopathologic characteristics including prognosis of the patients. TS expression was evaluated by immunohistochemical staining using TS106 monoclonal antibody in 103 locally advanced gastric cancer patients (stage IB-IV) who underwent 5-fluorouracil (5-FU) and doxorubicin-based adjuvant chemotherapy after curative resection. 65 patients (63%) had primary tumours with high TS expression (> or = 25% of tumour cells positive), and 38 patients (37%) demonstrated low TS expression (< 25% of tumour cells positive or no staining). High TS expression was associated with male gender (P = 0.002), poorly differentiated histology (P = 0.015), and mixed type in Lauren's classification (P = 0.027). There were no statistically significant differences in 4-year disease-free survival (60.0% vs. 57.2%, P = 0.548) and overall survival (59.6% vs. 59.3%, P = 0.792) between high-TS group and low-TS group. In conclusion, although high TS expression was associated with poorly differentiated histology and mixed type in Lauren's classification, it did not predict poor disease-free and overall survival in gastric cancer patients treated with 5-FU and doxorubicin-based adjuvant chemotherapy after curative resection. Further prospective studies including the evaluation of other biological markers associated with the resistance to 5-FU and doxorubicin are necessary.
MeSH terms
AdultAgedAntineoplastic Combined Chemotherapy Protocols/therapeutic use*Chemotherapy, AdjuvantCombined Modality TherapyDoxorubicin/administration & dosageFemaleFluorouracil/administration & dosageFollow-Up StudiesHumansImmunohistochemistryMaleMiddle AgedStomach/drug effectsStomach/enzymologyStomach/pathologyStomach Neoplasms/drug therapy*Stomach Neoplasms/enzymologyStomach Neoplasms/surgerySurvival AnalysisThymidylate Synthase/biosynthesisThymidylate Synthase/drug effects*Treatment Outcome
DOI
10.1054/bjoc.2000.1553
PMID
11161374
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
Journal Papers > School of Medicine / Graduate School of Medicine > Hematology-Oncology
AJOU Authors
최, 진혁임, 호영남, 동기김, 현수김, 효철조, 용관김, 명욱주, 희재이, 기범
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