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Vascular endothelial growth factor in the serum of patients with non-small cell lung cancer: correlation with platelet and leukocyte counts.

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dc.contributor.authorChoi, JH-
dc.contributor.authorKim, HC-
dc.contributor.authorLim, HY-
dc.contributor.authorNam, DK-
dc.contributor.authorKim, HS-
dc.contributor.authorYi, JW-
dc.contributor.authorChun, M-
dc.contributor.authorOh, YT-
dc.contributor.authorKang, S-
dc.contributor.authorPark, KJ-
dc.contributor.authorHwang, SC-
dc.contributor.authorLee, YH-
dc.contributor.authorHahn, MH-
dc.date.accessioned2011-08-19T07:13:40Z-
dc.date.available2011-08-19T07:13:40Z-
dc.date.issued2001-
dc.identifier.issn0169-5002-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/3837-
dc.description.abstractBACKGROUND: Vascular endothelial growth factor (VEGF) is a potent angiogenic peptide expressed in a wide variety of tumors, and it stimulates angiogenesis and increases vascular permeability. Increased expression of VEGF may be associated with advanced stage and poor prognosis in patients with non-small cell lung cancer (NSCLC).



METHODS: Using enzyme-linked immunosorbent assay, the levels of VEGF were determined in serum from 41 patients with untreated NSCLC (Stage: IIB, 3; IIIA, 6; IIIB, 17; IV, 15; Histology: squamous cell carcinoma, 18; adenocarcinoma. 14; undetermined, 9).



RESULTS: The median VEGF level was 312 pg/ml, ranging from 70 to 1440 pg/ml. Patients were divided into high VEGF (>312 pg/ml) and low VEGF (< or =312 pg/ml) groups using the median value as a cut-off. There were no significant associations between the serum VEGF levels and various clinicopathologic characteristics including age, gender, histologic type, stage and treatment. A significant positive correlation was found between serum VEGF levels and platelet counts (r=0.495; P=0.001). In addition, serum VEGF levels also correlated with leukocyte counts (r=0.478; P=0.002). In seven patients with measurement of follow-up serum VEGF levels at the end of treatment (chemotherapy and/or radiotherapy), the median serum VEGF level significantly decreased after the treatment (416 pg/ml; range, 96-812 pg/ml vs. 185 pg/ml; range, 49-487 pg/ml; P=0.028). However, the median platelet count (317,000/microl; range, 190,000-395,000/microl vs. 246,000/microl; range, 72,000-271,000/microl; P=0.028) and leukocyte count (10,000/microl; range, 8700-17,200/microl vs. 5100/microl; range, 3900-9500/microl; P=0.018) also decreased after the treatment. There was no statistically significant difference in the median survival of the patients between high VEGF group and low VEGF group (8 months vs. 9 months, P=0.647).



CONCLUSIONS: Although serum VEGF level was significantly associated with platelet and leukocyte counts in NSCLC patients, it did not correlate with tumor burden and prognosis of the patients.
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dc.language.isoen-
dc.subject.MESHAdenocarcinoma-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHCarcinoma, Non-Small-Cell Lung-
dc.subject.MESHCarcinoma, Squamous Cell-
dc.subject.MESHEndothelial Growth Factors-
dc.subject.MESHEnzyme-Linked Immunosorbent Assay-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLeukocyte Count-
dc.subject.MESHLung Neoplasms-
dc.subject.MESHLymphokines-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPlatelet Count-
dc.subject.MESHPrognosis-
dc.subject.MESHVascular Endothelial Growth Factor A-
dc.subject.MESHVascular Endothelial Growth Factors-
dc.titleVascular endothelial growth factor in the serum of patients with non-small cell lung cancer: correlation with platelet and leukocyte counts.-
dc.typeArticle-
dc.identifier.pmid11551412-
dc.identifier.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0169500201002008-
dc.contributor.affiliatedAuthor최, 진혁-
dc.contributor.affiliatedAuthor김, 효철-
dc.contributor.affiliatedAuthor임, 호영-
dc.contributor.affiliatedAuthor남, 동기-
dc.contributor.affiliatedAuthor김, 현수-
dc.contributor.affiliatedAuthor전, 미선-
dc.contributor.affiliatedAuthor오, 영택-
dc.contributor.affiliatedAuthor강, 승희-
dc.contributor.affiliatedAuthor박, 광주-
dc.contributor.affiliatedAuthor황, 성철-
dc.contributor.affiliatedAuthor이, 이형-
dc.type.localJournal Papers-
dc.citation.titleLung cancer (Amsterdam, Netherlands)-
dc.citation.volume33-
dc.citation.number2-3-
dc.citation.date2001-
dc.citation.startPage171-
dc.citation.endPage179-
dc.identifier.bibliographicCitationLung cancer (Amsterdam, Netherlands), 33(2-3). : 171-179, 2001-
dc.identifier.eissn1872-8332-
dc.relation.journalidJ001695002-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Hematology-Oncology
Journal Papers > School of Medicine / Graduate School of Medicine > Surgery
Journal Papers > School of Medicine / Graduate School of Medicine > Radiation Oncology
Journal Papers > School of Medicine / Graduate School of Medicine > Pulmonary & Critical Care Medicine
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Science
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