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Potentiated necrosis of cultured cortical neurons by neurotrophins.

Authors
Koh, JY; Gwag, BJ; Lobner, D; Choi, DW
Citation
Science, 268(5210):573-575, 1995
Journal Title
Science
ISSN
0193-4511
Abstract
The effects of neurotrophins on several forms of neuronal degeneration in murine cortical cell cultures were examined. Consistent with other studies, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5 all attenuated the apoptotic death induced by serum deprivation or exposure to the calcium channel antagonist nimodipine. Unexpectedly, however, 24-hour pretreatment with these same neurotrophins markedly potentiated the necrotic death induced by exposure to oxygen-glucose deprivation or N-methyl-D-aspartate. Thus, certain neurotrophins may have opposing effects on different types of death in the same neurons.
MeSH terms
AnimalsApoptosis/drug effectsBrain-Derived Neurotrophic FactorCalcium/metabolismCell Death/drug effectsCells, CulturedCerebral Cortex/cytologyDizocilpine Maleate/pharmacologyMiceN-Methylaspartate/pharmacologyNecrosisNerve Degeneration/*drug effectsNerve Growth Factors/*pharmacologyNerve Tissue Proteins/pharmacologyNeurons/*cytology/drug effects/pathologyNeurotrophin 3Quinoxalines/pharmacologyReceptors, AMPA/antagonists & inhibitors
PMID
7725105
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pharmacology
AJOU Authors
곽, 병주
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