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A murine model of toluene diisocyanate-induced asthma can be treated with matrix metalloproteinase inhibitor.

DC Field Value Language
dc.contributor.authorLee, YC-
dc.contributor.authorSong, CH-
dc.contributor.authorLee, HB-
dc.contributor.authorOh, JL-
dc.contributor.authorRhee, YK-
dc.contributor.authorPark, HS-
dc.contributor.authorKoh, GY-
dc.date.accessioned2011-08-22T02:05:56Z-
dc.date.available2011-08-22T02:05:56Z-
dc.date.issued2001-
dc.identifier.issn0091-6749-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/3856-
dc.description.abstractBACKGROUND: Toluene diisocyanate (TDI) is a leading cause of occupational asthma. TDI-induced asthma is an inflammatory disease of the airways that is associated with airway remodeling. However, there are little data available on the role of matrix metalloproteinases (MMPs) in TDI-induced asthma.



OBJECTIVE: We evaluated whether MMP-9 participates in the airway inflammation in TDI-induced asthma. An additional aim of the present study was to determine whether MMP inhibitors could be effective therapeutic agents for TDI-induced asthma.



METHODS: We developed a murine model of TDI-induced asthma to examine the involvement of MMPs by performing 2 sensitizations with 3% TDI and 1 challenge with 1% TDI using ultrasonic nebulization.



RESULTS: Murine TDI-induced asthma includes findings of (1) increased inflammatory cells, including neutrophils, lymphocytes, and eosinophils; (2) histologic changes, including infiltration of inflammatory cells around bronchioles, thickened airway epithelium, and accumulation of mucus and debris in the bronchioles; (3) increased MMP-9 activity in inflammatory cells in the airway lumen; and (4) airway hyperresponsiveness. Administration of an MMP inhibitor remarkably reduced all these pathophysiologic findings.



CONCLUSION: We conclude that TDI-induced occupational asthma is associated with the induction of MMP-9 in inflammatory cells, and the inhibition of MMP-9 may be a good therapeutic strategy.
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dc.language.isoen-
dc.subject.MESHAnimals-
dc.subject.MESHAsthma-
dc.subject.MESHBronchoalveolar Lavage Fluid-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHFemale-
dc.subject.MESHMatrix Metalloproteinase 9-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred BALB C-
dc.subject.MESHProtease Inhibitors-
dc.subject.MESHToluene 2,4-Diisocyanate-
dc.titleA murine model of toluene diisocyanate-induced asthma can be treated with matrix metalloproteinase inhibitor.-
dc.typeArticle-
dc.identifier.pmid11742282-
dc.identifier.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0091-6749(01)80684-9-
dc.contributor.affiliatedAuthor박, 해심-
dc.type.localJournal Papers-
dc.identifier.doi10.1067/mai.2001.120132-
dc.citation.titleThe Journal of allergy and clinical immunology-
dc.citation.volume108-
dc.citation.number6-
dc.citation.date2001-
dc.citation.startPage1021-
dc.citation.endPage1026-
dc.identifier.bibliographicCitationThe Journal of allergy and clinical immunology, 108(6). : 1021-1026, 2001-
dc.identifier.eissn1097-6825-
dc.relation.journalidJ000916749-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
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