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Oral administration of IL-12 suppresses anaphylactic reactions in a murine model of peanut hypersensitivity.

Authors
Lee, SY; Huang, CK; Zhang, TF; Schofield, BH; Burks, AW; Bannon, GA; Sampson, HA; Li, XM
Citation
Clinical immunology (Orlando, Fla.), 101(2):220-228, 2001
Journal Title
Clinical immunology (Orlando, Fla.)
ISSN
1521-66161521-7035
Abstract
There is no satisfactory therapeutic intervention for peanut allergy, which accounts for most life-threatening food allergic reactions. Since IL-12 has been found to inhibit allergic airway responses in a mouse model of asthma and to cure Th2 cytokine-mediated murine schistosomiasis, we hypothesized that IL-12 treatment might also inhibit peanut allergic reactions. Consequently, we investigated the effects of oral IL-12 treatment in a murine model of peanut allergy and found that oral administration of liposome encapsulated rIL-12 could both prevent and reverse peanut hypersensitivity and could reduce histamine release, peanut-specific serum IgE and IgG1, and fecal IgA levels. Oral IL-12 treatment also increased IFN-gamma but did not decrease IL-4 or IL-5 levels. We conclude that oral rIL-12 treatment has therapeutic as well as preventive effects on peanut allergy, which are associated with increased IFN-gamma production.
MeSH terms
Administration, OralAnaphylaxis/prevention & control*AnimalsArachis hypogaea/immunologyFemaleImmunoglobulin A, Secretory/analysisImmunoglobulin E/bloodImmunoglobulin G/classificationInterferon-gamma/analysisInterleukin-12/administration & dosage*Interleukin-4/analysisInterleukin-5/analysisLymphocyte Activation/drug effectsMiceMice, Inbred C3HPeanut Hypersensitivity/drug therapy*
DOI
10.1006/clim.2001.5122
PMID
11683581
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pediatrics & Adolescent Medicine
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