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Haloperidol and clozapine increase neural activity in the rat prefrontal cortex.

Authors
Kim, YB; Jang, J; Chung, Y; Baeg, EH; Kim, HT; Mook-Jung, I; Kim, SU; Jung, MW; Chung, YK
Citation
Neuroscience letters, 298(3):217-221, 2001
Journal Title
Neuroscience letters
ISSN
0304-39401872-7972
Abstract
Haloperidol and clozapine have been widely used to alleviate schizophrenic symptoms, but their physiological effects in the prefrontal cortex (PFC) are not known. Effects of haloperidol and clozapine on single unit activity were investigated in the medial PFC of anesthetized rats. Injection (intraperitoneal) of haloperidol (1 mg/kg) or clozapine (20 mg/kg) significantly elevated discharge rates of PFC neurons. Considering that hypofrontality is one characteristic of schizophrenic symptoms, these results raise the possibility that enhancement of PFC neural activity contributes to therapeutic effects of haloperidol and clozapine.
MeSH terms
Action Potentials/drug effectsAction Potentials/physiologyAnimalsAntipsychotic Agents/pharmacology*Clozapine/pharmacology*ElectrophysiologyHaloperidol/pharmacology*MaleNeurons/drug effectsNeurons/physiologyPrefrontal Cortex/cytologyPrefrontal Cortex/drug effects*Prefrontal Cortex/physiology*RatsRats, Sprague-DawleySchizophrenia/drug therapySchizophrenia/physiopathology
PMID
11165445
Appears in Collections:
Journal Papers > Research Organization > Brain Disease Research Center
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
Journal Papers > Research Organization > Institute for Medical Sciences
Journal Papers > School of Medicine / Graduate School of Medicine > Psychiatry & Behavioural Sciences
AJOU Authors
묵, 인희김, 승업정, 민환정, 영기
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