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Delayed rectifier potassium currents induced in activated rat microglia set the resting membrane potential.

Authors
Chung, S; Joe, E; Soh, H; Lee, MY; Bang, HW
Citation
Neuroscience letters, 242(2):73-76, 1998
Journal Title
Neuroscience letters
ISSN
0304-39401872-7972
Abstract
The delayed rectifying outward K+ (IK) current was measured in lipopolysaccharide (LPS)-activated cultured rat microglial cells by using whole-cell patch clamp method. The current showed 'window current' where channels were available for activation but never fully inactivated. At near resting membrane potential some part of the current was able to be activated by depolarization. Among the several K+ channel blockers tested, only 4-aminopyridine (4-AP) was able to block most of the current and depolarize the membrane potential reversibly. These results suggest that 4-AP sensitive IK current plays a direct role of setting the resting membrane potential in LPS-activated microglia.
MeSH terms
4-Aminopyridine/pharmacologyAnimalsAstrocytes/cytologyCells, CulturedDelayed Rectifier Potassium ChannelsIon Channel Gating/physiologyLipopolysaccharidesMembrane Potentials/physiologyMicroglia/*chemistry/drug effects/*physiologyPatch-Clamp TechniquesPotassium Channels/*physiology*Potassium Channels, Voltage-GatedRatsRats, Sprague-Dawley
PMID
9533397
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pharmacology
AJOU Authors
조, 은혜
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