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Nerve growth factor potentiates the oxidative necrosis of striatal cholinergic neurons.

Authors
Park, EC; Jou, I; Gwag, BJ
Citation
Neuroreport, 9(4):687-690, 1998
Journal Title
Neuroreport
ISSN
0959-49651473-558X
Abstract
We examined the effects of nerve growth factor (NGF) on free radical neurotoxicity in striatal cell cultures. Following exposure to 30 microM Fe2+ or 1 mM L-buthionine-[S,R]-sulfoximine (BSO), an inhibitor of gamma-glutamylcysteine synthetase, striatal neurons underwent cell body swelling and then widespread death over the next 24 h. The degeneration was prevented by addition of 100 microM trolox, an antioxidant. Addition of 100 ng/ml BDNF beginning 12 h before Fe2+ or BSO potentiated necrosis of most striatal neurons after exposure to 10 microM Fe2+ or 1 mM BSO. In contrast, treatment with 100 ng/ml NGF selectively potentiated the oxidative degeneration of striatal cholinergic neurons. The present findings provide additional evidence that NGF, like other neurotrophins, can potentiate oxidative neuronal cell necrosis.
MeSH terms
6-Cyano-7-nitroquinoxaline-2,3-dione/pharmacologyAcetylcholinesterase/metabolismAnimalsAntioxidants/pharmacologyBrain-Derived Neurotrophic Factor/pharmacologyButhionine Sulfoximine/*toxicityCells, CulturedChromans/*pharmacologyCorpus Striatum/*cytology/physiologyCycloheximide/pharmacologyDizocilpine Maleate/pharmacologyDrug SynergismFetusFree RadicalsIron/*toxicityNecrosisNerve DegenerationNerve Growth Factors/*toxicityNeuroglia/cytology/*drug effects/pathologyNeurons/cytology/*drug effects/pathologyNeurotoxins/*toxicityRatsRats, Sprague-Dawley
PMID
9559939
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pharmacology
AJOU Authors
주, 일로곽, 병주
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