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The cDNA cloning and ontogeny of mouse alpha-synuclein.

Authors
Hong, L; Ko, HW; Gwag, BJ; Joe, E; Lee, S; Kim, YT; Suh, YH
Citation
Neuroreport, 9(6):1239-1243, 1998
Journal Title
Neuroreport
ISSN
0959-49651473-558X
Abstract
Alpha-synuclein has been implicated in the pathogenesis of Parkinson's disease. To investigate the role of alpha-synuclein in the brain, the cDNA clone encoding the mouse cognate of the human alpha-synuclein was isolated from a mouse brain cDNA library. The open reading frame coded for 140 amino acids that share 95% identity with human alpha-synuclein. Northern blot analysis showed that alpha-synuclein mRNA was primarily expressed in brain and spleen of adult mouse. In situ hybridization histochemistry revealed the highest expression of alpha-synuclein mRNA in the hippocampal formation and neocortex of the adult mouse. alpha-Synuclein mRNA expression in the brain was first observed in the hippocampus and neocortex on postnatal day 1. Levels of alpha-synuclein mRNA in these forebrain areas were nearly maximal at postnatal day 7 and remained relatively high until the adult stage. alpha-Synuclein mRNA was expressed in the liver transiently during embryogenesis.
MeSH terms
Amino Acid SequenceAnimalsBase SequenceBrain/growth & development/*metabolismCloning, MolecularDNA, Complementary/*isolation & purification*Genes, DominantHumansMiceMolecular Sequence DataMutationNerve Tissue Proteins/*geneticsParkinson Disease/genetics/*metabolismPhenotypeRNA, Messenger/*analysisSequence Homology, Nucleic AcidSynucleinsalpha-Synuclein
PMID
9601701
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pharmacology
AJOU Authors
곽, 병주조, 은혜
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