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Modulation of membrane potential by extracellular pH in activated microglia in rats.

Authors
Chung, S; Lee, MY; Soh, H; Jung, W; Joe, E
Citation
Neuroscience letters, 249(2-3):139-142, 1998
Journal Title
Neuroscience letters
ISSN
0304-39401872-7972
Abstract
Activation of cultured rat microglial cells by lipopolysaccharide (LPS) induced delayed rectifying outward K+ (I(K)) current. I(K) current was reported to have 'window current', playing a direct role in setting the membrane potential in activated microglia. We used whole-cell patch clamp method to measure the effect of extracellular pH on I(K) current. When pH was changed from 7.4 to 6.4, the activation curve of I(K) current shifted to the right by about 13 mV. Thus, extracellular acidification reduced the window current, resulting in membrane depolarization. These results suggest that extracellular pH regulate the membrane potential in activated microglia.
MeSH terms
AnimalsAnimals, NewbornHydrogen-Ion ConcentrationLipopolysaccharides/pharmacologyMembrane Potentials/*physiologyMicroglia/drug effects/*physiologyPatch-Clamp TechniquesPotassium/*pharmacokineticsRatsRats, Sprague-Dawley
PMID
9682836
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pharmacology
AJOU Authors
조, 은혜
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