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Expression of phospholipase C-gamma1 in experimental cholesteatoma using Mongolian gerbils.

Authors
Park, K; Chun, YM; Lee, DH
Citation
Acta oto-laryngologica, 121(4):477-480, 2001
Journal Title
Acta oto-laryngologica
ISSN
0001-64891651-2251
Abstract
Phospholipase C (PLC)-gamma1 is known to play a central role in ligand-mediated signal transduction for cell proliferation. The purpose of this study was to elucidate the distribution of PLC-gamma1 in deep meatal skin, retroauricular skin and cholesteatoma matrix of experimental animals. We induced canal ligation cholesteatoma using Mongolian gerbils and investigated the expression of PLC-gamma1 in this model by using Western blot analysis and immunohistochemistry. By Western blot analysis, considerably higher levels of PLC-gamma1 protein were detectable in experimental cholesteatoma. On immunohistochemistry, experimental cholesteatoma showed more intense immunolabeling of PLC-gamma1 protein than deep meatal skin and retroauricular skin. In conclusion, overexpression of PLC-gamma1 may in part contribute to abnormal proliferation and differentiation of experimental cholesteatoma in Mongolian gerbils.
MeSH terms
AnimalsBlotting, WesternCell Movement/physiologyCholesteatoma, Middle Ear/enzymology*Cholesteatoma, Middle Ear/physiopathologyEar, Middle/enzymologyEar, Middle/pathologyEar, Middle/physiopathologyGerbillinaeIsoenzymes/metabolism*Models, Animal*Phospholipase C gammaType C Phospholipases/metabolism*
PMID
11508507
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Otolaryngology
AJOU Authors
박, 기현전, 영명
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