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The correlation of MHC haplotype and development of Behçet's disease-like symptoms induced by herpes simplex virus in several inbred mouse strains.

Sohn, S; Lee, ES; Lee, S
Journal of dermatological science, 26(3):173-181, 2001
Journal Title
Journal of dermatological science
It has been postulated that human leukocyte antigen (HLA)-B51 is associated with Behçet's disease. In previous study, we induced Behçet's disease-like symptoms in ICR mice inoculated with herpes simplex virus. In this study, several inbred mouse strains -- B10.BR (H-2k), B10.RIII (H-2r), C57BL/6 (H-2b), C3H/He (H-2k), Balb/c (H-2d) -- which had different types of major histocompatibility complex (MHC), were inoculated with herpes simplex virus type 1 (KOS strain) in order to demonstrate the role of histocompatibility antigen in the development of Behçet's disease-like symptoms. Behçet's disease-like symptoms developed in 40-50% of B10.BR, B10.RIII and C57BL/6 strains, but in only 2% of C3H/He and Balb/c. B10.BR and C3H/He strains had a common haplotype (H-2k) but the rate of manifestation was different. So, we conclude that MHC is not directly correlated with development of Behçet's disease-like symptoms in the animal model of herpes simplex virus induced Behçet's disease-like symptoms.
MeSH terms
AnimalsBehcet Syndrome/pathologyBehcet Syndrome/virology*Cell SeparationCytokines/metabolismFlow CytometryHaplotypes*Herpes Simplex/complications*Herpesvirus 1, Human*Major Histocompatibility Complex/genetics*MiceMice, Inbred Strains/genetics*Mice, Inbred Strains/virology*Polymerase Chain ReactionSpleen/cytologySpleen/metabolism
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Microbiology
Journal Papers > School of Medicine / Graduate School of Medicine > Dermatology
AJOU Authors
손, 성향이, 은소이, 성낙
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