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Experimental studies on the antiviral agent famciclovir in Behçet's disease symptoms in ICR mice.

Authors
Sohn, S; Bang, D; Lee, ES; Kwon, HJ; Lee, SI; Lee, S
Citation
The British journal of dermatology, 145(5):799-804, 2001
Journal Title
The British journal of dermatology
ISSN
0007-09631365-2133
Abstract
BACKGROUND: Chronic oral aphthae, recurrent genital ulcers and uveitis are the three main manifestations of Behçet's disease (BD). The aetiopathogenesis of BD is still obscure, but herpes simplex virus (HSV) is one of the possible causal factors. Various kinds of drugs, including immunosuppressants and aciclovir have been used in treatment, but effectiveness is variable.



OBJECTIVES: To demonstrate the efficacy of famciclovir, an antiviral compound that acts against HSV, varicella-zoster virus and hepatitis B virus, in a murine model of BD.



METHODS: Using the HSV-induced BD mouse model, famciclovir was administered variously before and after inoculation or from the day of lesion occurrence, with appropriate controls. Ulceration of the mouth and genital skin and eye involvement were monitored. In addition, spleen cytokine expression was measured by polymerase chain reaction.



RESULTS: Pretreatment and concurrent treatment did not affect the occurrence of BD, but treatment from the appearance of lesions was effective in improving BD and preventing recurrence. After famciclovir, interleukin 2 expression correlated with the recurrence of BD symptoms.



CONCLUSIONS: This model suggests the possible role of immune response to viral infection in the development and activation of BD. The study provides a rationale for clinical trials of famciclovir in the human form of BD.
MeSH terms
2-Aminopurine/analogs & derivatives*2-Aminopurine/therapeutic use*AnimalsAntiviral Agents/therapeutic use*Behcet Syndrome/drug therapy*Behcet Syndrome/immunologyBehcet Syndrome/virologyDisease Models, AnimalHerpes Simplex/complicationsHerpes Simplex/drug therapyInterleukin-2/metabolismMiceMice, Inbred ICRProdrugs/therapeutic use*RecurrenceReverse Transcriptase Polymerase Chain Reaction
PMID
11736905
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Microbiology
Journal Papers > School of Medicine / Graduate School of Medicine > Dermatology
AJOU Authors
손, 성향이, 은소이, 성낙
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