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Adverse pregnancy outcome after a false-positive screen for Down syndrome using multiple markers.

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dc.contributor.authorPergament, E-
dc.contributor.authorStein, AK-
dc.contributor.authorFiddler, M-
dc.contributor.authorCho, NH-
dc.contributor.authorKupferminc, MJ-
dc.date.accessioned2011-08-24T02:11:36Z-
dc.date.available2011-08-24T02:11:36Z-
dc.date.issued1995-
dc.identifier.issn0029-7844-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/3916-
dc.description.abstractOBJECTIVE: To assess the relative risk of an adverse pregnancy outcome in women whose multiple-marker screening (maternal serum alpha-fetoprotein [MSAFP], unconjugated estriol [E3], and hCG levels, and age) indicating an increased risk for Down syndrome (more than 1:250) was not confirmed by amniocentesis.



METHODS: Fifty-eight women with false-positive screens for Down syndrome were matched with a control group of 116 women whose screens indicated a risk for Down syndrome of less than 1:250. The risk for adverse pregnancy outcome was compared for the two groups, and the roles of MSAFP, unconjugated E3, and hCG as predictors of adverse pregnancy outcome were determined.



RESULTS: Women with false-positive screens for Down syndrome were significantly different from their matched controls in the incidence of preterm delivery (20.6 versus 8.6%, respectively), preeclampsia (6.9 versus 0%), small for gestational age newborns (5.2 versus 0%), and fetal demise after 20 weeks' gestation (5.2 versus 0%). An adverse outcome occurred in 19 of 58 pregnancies (32.8%) in the study group and in 14 of 116 matched control pregnancies (12%) (odds ratio [OR] 3.5, 95% confidence interval [CI] 1.6-7.8; P < .01). Unconjugated E3 of 0.75 multiples of the mean (MoM) or less was significantly associated with adverse pregnancy outcome after controlling for the effects of MSAFP and hCG (OR 2.5, 95% CI 1.13-5.55; P < .02).



CONCLUSION: One in three women with a false-positive screen for Down syndrome may experience an adverse pregnancy outcome. In this study, unconjugated E3 of 0.75 MoM or less appeared to be a better predictor of adverse pregnancy outcome than were MSAFP and hCG levels.
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dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAmniocentesis-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHChorionic Gonadotropin-
dc.subject.MESHConfidence Intervals-
dc.subject.MESHDown Syndrome-
dc.subject.MESHEstriol-
dc.subject.MESHFalse Positive Reactions-
dc.subject.MESHFemale-
dc.subject.MESHFetal Diseases-
dc.subject.MESHHumans-
dc.subject.MESHMaternal Age-
dc.subject.MESHOdds Ratio-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHPregnancy-
dc.subject.MESHPregnancy Outcome-
dc.subject.MESHPrenatal Diagnosis-
dc.subject.MESHRisk Factors-
dc.subject.MESHalpha-Fetoproteins-
dc.titleAdverse pregnancy outcome after a false-positive screen for Down syndrome using multiple markers.-
dc.typeArticle-
dc.identifier.pmid7542379-
dc.contributor.affiliatedAuthor조, 남한-
dc.type.localJournal Papers-
dc.citation.titleObstetrics and gynecology-
dc.citation.volume86-
dc.citation.number2-
dc.citation.date1995-
dc.citation.startPage255-
dc.citation.endPage258-
dc.identifier.bibliographicCitationObstetrics and gynecology, 86(2). : 255-258, 1995-
dc.identifier.eissn1873-233X-
dc.relation.journalidJ000297844-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Preventive Medicine & Public Health
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