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Lipopolysaccharide inhibits induction of long-term potentiation and depression in the rat hippocampal CA1 area.

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dc.contributor.authorJo, JH-
dc.contributor.authorPark, EJ-
dc.contributor.authorLee, JK-
dc.contributor.authorJung, MW-
dc.contributor.authorLee, CJ-
dc.date.accessioned2011-08-24T05:55:19Z-
dc.date.available2011-08-24T05:55:19Z-
dc.date.issued2001-
dc.identifier.issn0014-2999-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/3931-
dc.description.abstractWe examined the effects of lipopolysaccharide, a bacterial endotoxin, on synaptic plasticity in the rat hippocampal CA1 area in vitro. Lipopolysaccharide suppressed the induction of long-term potentiation elicited by tetanic stimulation and long-term depression, elicited by low-frequency stimulation of Schaffer collateral-commissural fibres at 10 and 50 microg/ml, respectively. Lipid A (1 microg/ml), the biologically active component of lipopolysaccharide, mimicked the effects of 10 microg/ml lipopolysaccharide on long-term potentiation and depression. Nifedipine, an L-type voltage-sensitive Ca(2+) channel antagonist, did not influence the induction of long-term potentiation and depression, whereas a high concentration of extracellular calcium enabled long-term potentiation induction in the presence of 10 microg/ml lipopolysaccharide. The NMDA receptor antagonist D,L-2-amino-5-phosphonovaleric acid (APV, 50 microM), nifedipine (10 microM) or lipopolysaccharide (10 or 50 microg/ml) partially reduced the magnitude of tetraethylammonium-induced long-term potentiation. Nifedipine combined with lipopolysaccharide completely blocked tetraethylammonium-induced long-term potentiation. Whole-cell voltage clamp recordings showed that lipopolysaccharide suppressed NMDA receptor-mediated excitatory postsynaptic currents (EPSCs). Our results indicate that lipopolysaccharide acutely modifies synaptic plasticity by blocking Ca(2+) entry through NMDA receptors, suggesting a possible mechanism for the amnesic action of bacterial infection.-
dc.language.isoen-
dc.subject.MESHAnimals-
dc.subject.MESHCalcium-
dc.subject.MESHCalcium Channel Blockers-
dc.subject.MESHExcitatory Postsynaptic Potentials-
dc.subject.MESHHippocampus-
dc.subject.MESHLipopolysaccharides-
dc.subject.MESHLong-Term Potentiation-
dc.subject.MESHNeuronal Plasticity-
dc.subject.MESHNifedipine-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHReceptors, N-Methyl-D-Aspartate-
dc.subject.MESHSynapses-
dc.subject.MESHTime Factors-
dc.titleLipopolysaccharide inhibits induction of long-term potentiation and depression in the rat hippocampal CA1 area.-
dc.typeArticle-
dc.identifier.pmid11430915-
dc.identifier.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0014299901010755-
dc.contributor.affiliatedAuthor정, 민환-
dc.type.localJournal Papers-
dc.citation.titleEuropean journal of pharmacology-
dc.citation.volume422-
dc.citation.number1-3-
dc.citation.date2001-
dc.citation.startPage69-
dc.citation.endPage76-
dc.identifier.bibliographicCitationEuropean journal of pharmacology, 422(1-3). : 69-76, 2001-
dc.identifier.eissn1879-0712-
dc.relation.journalidJ000142999-
Appears in Collections:
Journal Papers > Research Organization > Institute for Medical Sciences
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