35 268

Cited 0 times in

Integrin alpha V polymorphisms and haplotypes in a Korean population are associated with susceptibility to chronic hepatitis and hepatocellular carcinoma.

Authors
Lee, SK; Kim, MH; Cheong, JY; Cho, SW; Yang, SJ; Kwack, K
Citation
Liver international : official journal of the International Association for the Study of the Liver, 29(2):187-195, 2009
Journal Title
Liver international : official journal of the International Association for the Study of the Liver
ISSN
1478-32231478-3231
Abstract
BACKGROUND/AIMS: Integrins are cell surface receptors for extracellular matrix (ECM) proteins that initiate signalling pathways that modulate proliferation, survival, invasion or metastasis. Consequently, integrins are potential targets for the treatment of cancer. In this study, we investigated whether single nucleotide polymorphisms (SNPs) in integrin alpha(V) (ITGAV) in a Korean population were associated with chronic hepatitis B virus (HBV) infection and HBV-infected hepatocellular carcinoma (HCC).



PATIENTS AND METHODS: Thirteen ITGAV SNPs in 111 cases of chronic HBV infection, 86 cases of HBV-infected HCC and 107 cases of acute self-limited HBV infection were genotyped using Illumina's Sentrix array matrix (SAM) chip.



RESULTS: The ITGAV intron SNPs rs9333289 and rs11685758, the 3'-untranslated region SNP rs1839123 and haplotype 3 (T-T-A) were associated with enhanced susceptibility to HBV-infected HCC (OR=1.75-2.42; P=0.02-0.05), while the intron SNP rs2290083 was associated with both chronic infection and HBV-infected HCC (OR=1.73-2.01; P=0.01-0.04). In addition, both rs2290083 and ht1 (C-C-G) were associated with the age at which chronic infection occurred, as determined by Cox relative hazard analysis (RH=1.39-1.62, P=0.04-0.01)



CONCLUSION: ITGAV SNPs and haplotypes may be genetic factors that increase the susceptibility of Koreans to chronic HBV infection and HBV-infected HCC.
MeSH terms
AdultAgedCarcinoma, Hepatocellular/genetics*FemaleGenetic Predisposition to Disease/genetics*Haplotypes/geneticsHepatitis B, Chronic/genetics*HumansIntegrin alphaV/genetics*KoreaLinkage DisequilibriumLogistic ModelsMaleMiddle AgedModels, GeneticPolymorphism, Single Nucleotide/genetics
DOI
10.1111/j.1478-3231.2008.01843.x
PMID
18694400
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
AJOU Authors
정, 재연조, 성원
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse