5 193

Cited 0 times in

Pathogenic significance of neuronal migration disorders in temporal lobe epilepsy.

Authors
Lee, MC; Kim, GM; Woo, YJ; Kim, MK; Kim, JH; Nam, SC; Suh, JJ; Chung, WK; Lee, JS; Kim, HI; Choi, HY; Kim, SU
Citation
Human pathology, 32(6):643-648, 2001
Journal Title
Human pathology
ISSN
0046-81771532-8392
Abstract
To assess the epileptogenic lesions, a series of 202 cases with temporal lobectomy were analyzed histopathologically. The severity of hippocampal neuronal loss in patients with temporal lobe epilepsy was quantitatively analyzed and compared against autopsy controls of patients who died of nonneurologic disorders. For the histopathologic diagnosis of neuronal migration disorder (NMD), immunohistochemical stains for neurofilament protein (NF-M/H) and microtubule-associated protein 2 (MAP2) and Bielschowsky silver stains were routinely performed. Histopathology of NMD was classified by the 4-grade system. MAP2 immunoreactivity was useful in the identification of loss of normal polarization of dendrites in the abnormal neurons. NF-M/H immunohistochemistry and silver stains effectively labeled microscopic or occult lesions of NMD (grade II and III). Ammon hom sclerosis (AHS) was identified in 73.3% and NMD in 57.9%. There was more than 50% neuronal cell loss in 82.8% of AHS, and variable degrees of cell loss were observed in the dual-pathology groups. The frequency of dual pathology (both AHS and NMD) was 65.0% and showed relatively equal distributions in grades I, II, III, whereas the pure NMD group were classified predominantly as grades II and III. NMD might be a basic pathogenic substrate causing temporal lobe epilepsy. The dual pathology may indicate the presence of epileptogenic lesions in the neocortical and temporolimbic areas.
MeSH terms
Brain Neoplasms/complicationsBrain Neoplasms/diagnosisBrain Neoplasms/pathologyCell MovementEpilepsy, Temporal Lobe/complicationsEpilepsy, Temporal Lobe/pathology*Epilepsy, Temporal Lobe/surgeryHippocampus/pathologyHumansImmunohistochemistryMicrotubule-Associated Proteins/analysisNeurofilament Proteins/analysisNeurons/pathologyNeurons/physiology*Silver StainingTemporal Lobe/surgery
DOI
10.1053/hupa.2001.24997
PMID
11431720
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
AJOU Authors
김, 승업
Full Text Link
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse