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Adjuvant effect of polyadenylic.polyuridylic acid on antibody production of recombinant hepatitis B surface antigen in mice.

Authors
Park, SJ; Kim, WH; Han, KH; Chon, CY; Hahm, KB; Moon, YM; Kang, JK; Park, IS; Youn, JK
Citation
International journal of immunopharmacology, 17(6):513-516, 1995
Journal Title
International journal of immunopharmacology
ISSN
0192-0561
Abstract
The adjuvant effect of polyadenylic.polyuridylic acid [poly(A).poly(U)] on antibody production against recombinant hepatitis B surface antigen (rHBsAg) was investigated. Immunization of adult Balb/c mice with rHBsAg plus poly(A).poly(U) elicited significantly higher antibody responses than immunization of mice immunized with rHBsAg alone. Such an adjuvant effect was evident even in mice sensitized with subimmunogenic doses of the antigen.
MeSH terms
Adjuvants, Immunologic/*therapeutic useAnimalsAntibodies, Viral/*biosynthesis/drug effectsFemaleHepatitis B/*prevention & controlHepatitis B Surface Antigens/*immunologyMiceMice, Inbred BALB CPoly A-U/*therapeutic useVaccines, Synthetic/*immunology/therapeutic use
PMID
7499028
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Microbiology
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
AJOU Authors
함, 기백윤, 정구
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