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A novel disintegrin salmosin inhibits tumor angiogenesis.

DC Field Value Language
dc.contributor.authorKang, IC-
dc.contributor.authorLee, YD-
dc.contributor.authorKim, DS-
dc.date.accessioned2011-09-02-
dc.date.available2011-09-02-
dc.date.issued1999-
dc.identifier.issn0008-5472-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/3991-
dc.description.abstractSalmosin is a snake venom-derived novel disintegrin that antagonizes platelet aggregation. In this study, we investigated its functional specificity in tumor angiogenesis. Salmosin significantly inhibited bovine capillary endothelial cell proliferation induced by basic fibroblast growth factor but had no effect on normal growth of the cell. The basic fibroblast growth factor-induced in vivo angiogenesis in the chorioallantoic membrane was disrupted by salmosin treatment without affecting normal embryonic angiogenesis. Adhesion of the bovine capillary endothelial cells to vitronectin was also inhibited by the binding of salmosin to the alpha(v)beta3 integrin. Both the metastatic-tumor growth and the solid-tumor growth that developed in mice were effectively suppressed by salmosin treatment. Several lines of experimental evidence strongly suggest that the tumor-specific antiangiogenic activity of salmosin disrupts tumor growth by blocking the alpha(v)beta3 integrin that is expressed on the vascular endothelial cell surface.-
dc.language.isoen-
dc.subject.MESHAllantois-
dc.subject.MESHAnimals-
dc.subject.MESHAntineoplastic Agents-
dc.subject.MESHCarcinoma-
dc.subject.MESHCattle-
dc.subject.MESHCell Adhesion-
dc.subject.MESHCells, Cultured-
dc.subject.MESHChick Embryo-
dc.subject.MESHChorion-
dc.subject.MESHCrotalid Venoms-
dc.subject.MESHEndothelium, Vascular-
dc.subject.MESHFibroblast Growth Factor 2-
dc.subject.MESHLung Neoplasms-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred C57BL-
dc.subject.MESHNeoplasm Proteins-
dc.subject.MESHNeoplasm Transplantation-
dc.subject.MESHNeovascularization, Pathologic-
dc.subject.MESHOligopeptides-
dc.subject.MESHReceptors, Vitronectin-
dc.subject.MESHTumor Cells, Cultured-
dc.subject.MESHVitronectin-
dc.titleA novel disintegrin salmosin inhibits tumor angiogenesis.-
dc.typeArticle-
dc.identifier.pmid10446992-
dc.identifier.urlhttp://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=10446992-
dc.contributor.affiliatedAuthor이, 영돈-
dc.type.localJournal Papers-
dc.citation.titleCancer research-
dc.citation.volume59-
dc.citation.number15-
dc.citation.date1999-
dc.citation.startPage3754-
dc.citation.endPage3760-
dc.identifier.bibliographicCitationCancer research, 59(15). : 3754-3760, 1999-
dc.identifier.eissn1538-7445-
dc.relation.journalidJ000085472-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Anatomy
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