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A sesquiterpene, dehydrocostus lactone, inhibits the expression of inducible nitric oxide synthase and TNF-alpha in LPS-activated macrophages.

Authors
Lee, HJ; Kim, NY; Jang, MK; Son, HJ; Kim, KM; Sohn, DH; Lee, SH; Ryu, JH
Citation
Planta medica, 65(2):104-108, 1999
Journal Title
Planta medica
ISSN
0032-09431439-0221
Abstract
Nitric oxide (NO) and tumor necrosis factor alpha (TNF-alpha) are the major mediators produced in activated macrophages which contribute to the circulatory failure associated with septic shock. A sesquiterpene lactone compound (dehydrocostus lactone) isolated from the medicinal plant, Saussurea lappa, inhibited the production of NO in lipopolysaccharide (LPS)-activated RAW 264.7 cells by suppressing inducible nitric oxide synthase enzyme expression. This compound also decreased the TNF-alpha level in LPS-activated systems in vitro and in vivo. Thus, dehydrocostus lactone may be a possible candidate for the development of new drugs to treat endotoxemia accompanied by the overproduction of NO and TNF-alpha.
MeSH terms
AnimalsCell LineEnzyme Inhibitors/pharmacology*Lactones/pharmacology*Lipopolysaccharides/pharmacology*Macrophage Activation/drug effectsMacrophages/drug effects*Macrophages/enzymologyMacrophages/metabolismMaleMiceMice, Inbred ICRNitric Oxide Synthase/antagonists & inhibitors*Nitric Oxide Synthase Type IISesquiterpenes/pharmacology*Tumor Necrosis Factor-alpha/antagonists & inhibitors*
DOI
10.1055/s-1999-13968
PMID
10193198
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
AJOU Authors
이, 희주이, 수환
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